Randomized controlled trial of a positive affect intervention to reduce stress in people newly diagnosed with HIV; protocol and design for the IRISS study

Judith Tedlie Moskowitz*, Adam W. Carrico, Michael A. Cohn, Larissa G. Duncan, Cori Bussolari, Kristin Layous, Jen R. Hult, Alex Brousset, Paul Cotten, Stephanie Maurer, Martha E. Pietrucha, Michael Acree, Judith Wrubel, Mallory O. Johnson, Frederick M. Hecht, Susan Folkman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Increasing evidence suggests that positive affect plays an important role in adaptation to chronic illness, independent of levels of negative affects like depression. Positive affect may be especially beneficial for people in the midst of severe stress, such as the diagnosis of human immunodeficiency virus (HIV). As medical treatments for HIV have improved, the number of people living with HIV has increased, and prevention strategies tailored specifically to people living with HIV have become a priority. There is a need for effective, creative, client-centered interventions that can be easily disseminated to community treatment settings, but there are currently few established interventions for people who are newly diagnosed with HIV. We present the design and methods for a randomized trial in which we test the efficacy of one such skills-based intervention that targets positive affect as a novel mechanism of change. The proposed research builds on observational findings of the important unique functions of positive affect. We aim to determine whether a five-session theory-and evidence-based intervention designed to teach skills for increasing the frequency and intensity of daily positive affect does so, and whether this intervention has beneficial effects on subsequent psychological well-being, health behaviors, and physical health up to 15 months after diagnosis with HIV. This is a randomized controlled trial in a sample of adults recruited within 12 weeks of testing positive for HIV. The control group is attention-matched, and follow up assessments will be conducted immediately post intervention (approximately 5 months post diagnosis) and at 10 and 15 months post diagnosis. This study is an important next step in research concerning the adaptive functions of positive affect for people coping with HIV or other health-related life stress.

Original languageEnglish (US)
Pages (from-to)85-100
Number of pages16
JournalOpen Access Journal of Clinical Trials
StatePublished - Sep 22 2014


  • Coping
  • HIV diagnosis
  • Intervention
  • Physical health
  • Positive affect
  • RCT
  • Stress

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
  • Pharmacology (medical)


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