TY - JOUR
T1 - Randomized trial of a web-based intervention to address barriers to clinical trials
AU - Meropol, Neal J.
AU - Wong, Yu Ning
AU - Albrecht, Terrance
AU - Manne, Sharon
AU - Miller, Suzanne M.
AU - Flamm, Anne Lederman
AU - Benson, Al Bowen
AU - Buzaglo, Joanne
AU - Collins, Michael
AU - Egleston, Brian
AU - Fleisher, Linda
AU - Katz, Michael
AU - Kinzy, Tyler G.
AU - Liu, Tasnuva M.
AU - Margevicius, Seunghee
AU - Miller, Dawn M.
AU - Poole, David
AU - Roach, Nancy
AU - Ross, Eric
AU - Schluchter, Mark D.
N1 - Publisher Copyright:
© 2016 by American Society of Clinical Oncology. All rights reserved.
PY - 2016/2/10
Y1 - 2016/2/10
N2 - Purpose: Lack of knowledge and negative attitudes have been identified as barriers to participation in clinical trials by patients with cancer.Wedeveloped Preparatory Education About Clinical Trials (PRE-ACT), a theory-guided, Web-based, interactive computer program, to deliver tailored video educational content to patients in an effort to overcome barriers to considering clinical trials as a treatment option. Patients and Methods: A prospective, randomized clinical trial compared PRE-ACT with a control condition that provided general clinical trials information produced by the National Cancer Institute (NCI) in text format. One thousand two hundred fifty-five patients with cancer were randomly allocated before their initial visit with an oncologist to PRE-ACT (n = 623) or control (n = 632). PRE-ACT had three main components: assessment of clinical trials knowledge and attitudinal barriers, values assessment with clarification back to patients, and provision of a video library tailored to address each patient's barriers. Outcomes included knowledge and attitudes and preparation for decision making about clinical trials. Results: Both PRE-ACT and control interventions improved knowledge and attitudes (all P < .001) compared with baseline. Patients randomly allocated to PRE-ACT showed a significantly greater increase in knowledge (P < .001) and a significantly greater decrease in attitudinal barriers (P < .001) than did their control (text-only) counterparts. Participants in both arms significantly increased their preparedness to consider clinical trials (P < .001), and there was a trend favoring the PRE-ACT group (P < .09). PRE-ACT was also associated with greater patient satisfaction than was NCI text alone. Conclusion: These data show that patient education before the first oncologist visit improves knowledge, attitudes, and preparation for decision making about clinical trials. Both text and tailored video were effective. The PRE-ACT interactive video program was more effective than NCI text in improving knowledge and reducing attitudinal barriers.
AB - Purpose: Lack of knowledge and negative attitudes have been identified as barriers to participation in clinical trials by patients with cancer.Wedeveloped Preparatory Education About Clinical Trials (PRE-ACT), a theory-guided, Web-based, interactive computer program, to deliver tailored video educational content to patients in an effort to overcome barriers to considering clinical trials as a treatment option. Patients and Methods: A prospective, randomized clinical trial compared PRE-ACT with a control condition that provided general clinical trials information produced by the National Cancer Institute (NCI) in text format. One thousand two hundred fifty-five patients with cancer were randomly allocated before their initial visit with an oncologist to PRE-ACT (n = 623) or control (n = 632). PRE-ACT had three main components: assessment of clinical trials knowledge and attitudinal barriers, values assessment with clarification back to patients, and provision of a video library tailored to address each patient's barriers. Outcomes included knowledge and attitudes and preparation for decision making about clinical trials. Results: Both PRE-ACT and control interventions improved knowledge and attitudes (all P < .001) compared with baseline. Patients randomly allocated to PRE-ACT showed a significantly greater increase in knowledge (P < .001) and a significantly greater decrease in attitudinal barriers (P < .001) than did their control (text-only) counterparts. Participants in both arms significantly increased their preparedness to consider clinical trials (P < .001), and there was a trend favoring the PRE-ACT group (P < .09). PRE-ACT was also associated with greater patient satisfaction than was NCI text alone. Conclusion: These data show that patient education before the first oncologist visit improves knowledge, attitudes, and preparation for decision making about clinical trials. Both text and tailored video were effective. The PRE-ACT interactive video program was more effective than NCI text in improving knowledge and reducing attitudinal barriers.
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U2 - 10.1200/JCO.2015.63.2257
DO - 10.1200/JCO.2015.63.2257
M3 - Article
C2 - 26700123
AN - SCOPUS:84958765343
SN - 0732-183X
VL - 34
SP - 469
EP - 478
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 5
ER -