RANTES production from CD4+ lymphocytes correlates with host genotype and rates of human immunodeficiency virus type 1 disease progression

William A. Paxton*, Avidan U. Neumann, Stanley Kang, Lisa Deutch, R. Clark Brown, Richard A. Koup, Steven M. Wolinsky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Several chemokine and chemokine receptor parameters were measured in peripheral blood mononuclear cells obtained from patients before they became infected with human immunodeficiency virus type 1 (HIV-1). After HIV-1 infection, the parameters were compared with plasma HIV-1 RNA levels and with rates of CD4+ lymphocyte decline. Patients who were heterozygous for the Δ32CCR5 allele had significantly higher levels of RANTES production from their CD4+ lymphocytes than did patients who did not carry the Δ32CCR5 allele (P = .01). Higher RANTES production levels from ex vivo-activated CD4+-enriched lymphocytes, but not CD8+ lymphocytes, correlated with lower plasma HIV-1 RNA levels 9-12 months after infection (P = .01) and with slower rates of CD4+ lymphocyte decline (P = .002). CCR5 expression levels on ex vivo - activated CD4+ lymphocytes did not correlate with markers of disease progression. These results further support the hypothesis that chemokine production levels are associated with HIV-1 replication in vivo.

Original languageEnglish (US)
Pages (from-to)1678-1681
Number of pages4
JournalJournal of Infectious Diseases
Volume183
Issue number11
DOIs
StatePublished - Jun 1 2001

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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