Rapid, accurate and simultaneous noninvasive assessment of right and left ventricular mass with nuclear magnetic resonance imaging using the snapshot gradient method

Kenneth M. McDonald*, Todd Parrish, Paul Wennberg, Arthur E. Stillman, Gary S. Francis, Jay N. Cohn, David Hunter

*Corresponding author for this work

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Left ventricular, and possibly also right ventricular, mass is an important determinant of prognosis in cardiovascular disease. Consequently, noninvasive estimation of ventricular mass may be an important clinical investigation. The ideal technique for this purpose would be widely available and accurate, employ short study times and avoid exposure to contrast agents and radiation. Conventional nuclear magnetic resonance (NMR) imaging fulfills most of these criteria, but it is time-consuming and expensive. Moreover, its accuracy in estimating right ventricular mass has yet to be assessed. Accordingly, high speed NMR imaging using the snapshot gradient echo technique was used to assess right and left ventricular mass in 10 dogs and the results were compared with values obtained at autopsy, which ranged from 26.1 to 52.9 and 61 to 119.8 g. respectively. The mean absolute difference between the NMR imaging estimates and autopsy findings was 2 ± 1.2 g (range 0.4 to 4.2) for right ventricular mass and 4.4 ± 1.7 g (range 1.8 to 6.6) for left ventricular mass. Total NMR imaging time was ≤5 min. These data demonstrate that high speed NMR imaging can be used to accurately estimate right as well as left ventricular mass.

Original languageEnglish (US)
Pages (from-to)1601-1607
Number of pages7
JournalJournal of the American College of Cardiology
Volume19
Issue number7
DOIs
StatePublished - Jun 1992

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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