Rapid declines in total lymphocyte count and hemoglobin in HIV infection begin at CD4 lymphocyte counts that justify antiretroviral therapy

Stephen J. Gange*, Bryan Lau, John Phair, Sharon A. Riddler, Roger Detels, Joseph B. Margolick

*Corresponding author for this work

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

We investigated whether the onset of rapid declines in total lymphocyte counts and hemoglobin levels might be useful for staging HIV disease and initiating antiretroviral therapy. Using data from the Multicenter AIDS Cohort Study, we found that accelerated declines in both markers generally precede AIDS by 1.2 years and occur when the CD4 lymphocyte counts fall below 350 cells/mm3. These markers may thus be suitable for monitoring disease and timing therapy initiation in resource-limited settings.

Original languageEnglish (US)
Pages (from-to)119-121
Number of pages3
JournalAIDS
Volume17
Issue number1
DOIs
StatePublished - Jan 3 2003

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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