Rapid detection of herpes-simplex-virus DNA in cerebrospinal fluid of patients with herpes simplex encephalitis

A. H. Rowley*, S. M. Wolinsky, R. J. Whitley, F. D. Lakeman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

223 Scopus citations

Abstract

Herpes-simplex-virus (HSV) DNA in cerebrospinal fluid was amplified by use of the polymerase chain reaction and identified by hybridisation to a specific oligonucleotide probe. Specimens of cerebrospinal fluid (CSF) from 4 of 4 patients with herpes simplex encephalitis were positive for HSV DNA, whereas CSF specimens from 6 patients with other central-nervous-system infections were negative. This technique may expedite diagnosis of herpes simplex encephalitis.

Original languageEnglish (US)
Pages (from-to)440-441
Number of pages2
JournalThe Lancet
Volume335
Issue number8687
DOIs
StatePublished - Feb 24 1990

ASJC Scopus subject areas

  • Medicine(all)

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