Rapid determination of the rate constant of agonist-induced association of single platelets

Lawrence L. Hause*, Gregory S. Retzinger, Patricia A. Megan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

We have developed a rapid and convenient method for determining the rate constant of association of single platelets. Using the concentration of single platelets prior to activation and that 0.25 min (15 s) after activation, this rate constant can be determined accurately without concern for reversibility of the aggregation process or need for statistical analysis. A linear relationship between initial platelet concentration and the rate constant of association is defined. The clinical utility of this association parameter is discussed.

Original languageEnglish (US)
Pages (from-to)105-112
Number of pages8
JournalThrombosis research
Volume61
Issue number2
DOIs
StatePublished - Jan 15 1991

Keywords

  • kinetics
  • platelet aggregation
  • platelet association

ASJC Scopus subject areas

  • Hematology

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