Abstract
We have developed a rapid and convenient method for determining the rate constant of association of single platelets. Using the concentration of single platelets prior to activation and that 0.25 min (15 s) after activation, this rate constant can be determined accurately without concern for reversibility of the aggregation process or need for statistical analysis. A linear relationship between initial platelet concentration and the rate constant of association is defined. The clinical utility of this association parameter is discussed.
Original language | English (US) |
---|---|
Pages (from-to) | 105-112 |
Number of pages | 8 |
Journal | Thrombosis research |
Volume | 61 |
Issue number | 2 |
DOIs | |
State | Published - Jan 15 1991 |
Funding
This work was supported in part by research funds from the Department of Pathology, Medical College of Wisconsin, by grant 89-GA-30 from the Wisconsin affiliate of the American Heart Association, and by a grant from the Lucille P. Markey Foundation. G.S. Retzinger is a Lucille P. Markey Scholar. We thank Pamela Sweet for preparation of the manuscript.
Keywords
- kinetics
- platelet aggregation
- platelet association
ASJC Scopus subject areas
- Hematology