Rapid dramatic alterations to the tumor microstructure in pancreatic cancer following irreversible electroporation ablation

Zhuoli Zhang; Weiguo Li; Daniel Procissi; Patrick Tyler; Reed A. Omary; Andrew C. Larson

doi:10.2217/nnm.13.72

Rapid dramatic alterations to the tumor microstructure in pancreatic cancer following irreversible electroporation ablation

Zhuoli Zhang, Weiguo Li, Daniel Procissi, Patrick Tyler, Reed A. Omary, Andrew C. Larson^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Aim: NanoKnife^® (Angiodynamics, Inc., NY, USA) or irreversible electroporation (IRE) is a newly available ablation technique to induce the formation of nanoscale pores within the cell membrane in targeted tissues. The purpose of this study was to elucidate morphological alterations following 30 min of IRE ablation in a mouse model of pancreatic cancer. Materials & methods: Immunohistochemistry markers were compared with diffusion-weighted MRI apparent diffusion coefficient measurements before and after IRE ablation. Results: Immunohistochemistry apoptosis index measurements were significantly higher in IRE-treated tumors than in controls. Rapid tissue alterations after 30 min of IRE ablation procedures (structural and morphological alterations along with significantly elevated apoptosis markers) were consistently observed and well correlated to apparent diffusion coefficient measurements. Discussion: This imaging assay offers the potential to serve as an in vivo biomarker for noninvasive detection of tumor response following IRE ablation.

Original language	English (US)
Pages (from-to)	1181-1192
Number of pages	12
Journal	Nanomedicine
Volume	9
Issue number	8
DOIs	https://doi.org/10.2217/nnm.13.72
State	Published - Jun 2014

Keywords

MRI biomarker
apoptosis
irreversible electroporation
pancreatic cancer
therapy response

ASJC Scopus subject areas

Bioengineering
Materials Science(all)
Biomedical Engineering
Medicine (miscellaneous)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/nnm.13.72

Cite this

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title = "Rapid dramatic alterations to the tumor microstructure in pancreatic cancer following irreversible electroporation ablation",

abstract = "Aim: NanoKnife{\textregistered} (Angiodynamics, Inc., NY, USA) or irreversible electroporation (IRE) is a newly available ablation technique to induce the formation of nanoscale pores within the cell membrane in targeted tissues. The purpose of this study was to elucidate morphological alterations following 30 min of IRE ablation in a mouse model of pancreatic cancer. Materials & methods: Immunohistochemistry markers were compared with diffusion-weighted MRI apparent diffusion coefficient measurements before and after IRE ablation. Results: Immunohistochemistry apoptosis index measurements were significantly higher in IRE-treated tumors than in controls. Rapid tissue alterations after 30 min of IRE ablation procedures (structural and morphological alterations along with significantly elevated apoptosis markers) were consistently observed and well correlated to apparent diffusion coefficient measurements. Discussion: This imaging assay offers the potential to serve as an in vivo biomarker for noninvasive detection of tumor response following IRE ablation.",

keywords = "MRI biomarker, apoptosis, irreversible electroporation, pancreatic cancer, therapy response",

author = "Zhuoli Zhang and Weiguo Li and Daniel Procissi and Patrick Tyler and Omary, {Reed A.} and Larson, {Andrew C.}",

year = "2014",

month = jun,

doi = "10.2217/nnm.13.72",

language = "English (US)",

volume = "9",

pages = "1181--1192",

journal = "Nanomedicine",

issn = "1743-5889",

publisher = "Future Medicine Ltd.",

number = "8",

}

TY - JOUR

T1 - Rapid dramatic alterations to the tumor microstructure in pancreatic cancer following irreversible electroporation ablation

AU - Zhang, Zhuoli

AU - Li, Weiguo

AU - Procissi, Daniel

AU - Tyler, Patrick

AU - Omary, Reed A.

AU - Larson, Andrew C.

PY - 2014/6

Y1 - 2014/6

N2 - Aim: NanoKnife® (Angiodynamics, Inc., NY, USA) or irreversible electroporation (IRE) is a newly available ablation technique to induce the formation of nanoscale pores within the cell membrane in targeted tissues. The purpose of this study was to elucidate morphological alterations following 30 min of IRE ablation in a mouse model of pancreatic cancer. Materials & methods: Immunohistochemistry markers were compared with diffusion-weighted MRI apparent diffusion coefficient measurements before and after IRE ablation. Results: Immunohistochemistry apoptosis index measurements were significantly higher in IRE-treated tumors than in controls. Rapid tissue alterations after 30 min of IRE ablation procedures (structural and morphological alterations along with significantly elevated apoptosis markers) were consistently observed and well correlated to apparent diffusion coefficient measurements. Discussion: This imaging assay offers the potential to serve as an in vivo biomarker for noninvasive detection of tumor response following IRE ablation.

AB - Aim: NanoKnife® (Angiodynamics, Inc., NY, USA) or irreversible electroporation (IRE) is a newly available ablation technique to induce the formation of nanoscale pores within the cell membrane in targeted tissues. The purpose of this study was to elucidate morphological alterations following 30 min of IRE ablation in a mouse model of pancreatic cancer. Materials & methods: Immunohistochemistry markers were compared with diffusion-weighted MRI apparent diffusion coefficient measurements before and after IRE ablation. Results: Immunohistochemistry apoptosis index measurements were significantly higher in IRE-treated tumors than in controls. Rapid tissue alterations after 30 min of IRE ablation procedures (structural and morphological alterations along with significantly elevated apoptosis markers) were consistently observed and well correlated to apparent diffusion coefficient measurements. Discussion: This imaging assay offers the potential to serve as an in vivo biomarker for noninvasive detection of tumor response following IRE ablation.

KW - MRI biomarker

KW - apoptosis

KW - irreversible electroporation

KW - pancreatic cancer

KW - therapy response

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Rapid dramatic alterations to the tumor microstructure in pancreatic cancer following irreversible electroporation ablation

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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