Rapid Dynamics of Signal-Dependent Transcriptional Repression by Capicua

Shannon E. Keenan, Shelby A. Blythe, Robert A. Marmion, Nareg J.V. Djabrayan, Eric F. Wieschaus, Stanislav Y. Shvartsman*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Using optogenetics, the MS2-MCP system, and ChIP-seq techniques, Keenan et al. investigate the dynamic transcriptional response of ERK signaling in the early Drosophila embryo. They show that ERK signaling relieves repression of genes on a short timescale and that repression can return when signal is removed.

Original languageEnglish (US)
Pages (from-to)794-801.e4
JournalDevelopmental Cell
Volume52
Issue number6
DOIs
StatePublished - Mar 23 2020

Keywords

  • Capicua
  • Drosophila
  • ERK
  • cellular signaling
  • development
  • optogenetics
  • transcriptional repression

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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  • Cite this

    Keenan, S. E., Blythe, S. A., Marmion, R. A., Djabrayan, N. J. V., Wieschaus, E. F., & Shvartsman, S. Y. (2020). Rapid Dynamics of Signal-Dependent Transcriptional Repression by Capicua. Developmental Cell, 52(6), 794-801.e4. https://doi.org/10.1016/j.devcel.2020.02.004