Rapid HIV testing for developing countries: The challenge of false-negative tests

Ram Yogev

doi:10.1117/12.924574

Rapid HIV testing for developing countries: The challenge of false-negative tests

Ram Yogev^*

^*Corresponding author for this work

Pediatrics

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

It is a common practice in resource-constrained countries to accept two positive rapid HIV antibody test results as diagnostic for HIV infection. Because these tests are inexpensive and results are obtained quickly, they are recommended by the WHO to "scale-up" HIV testing to increase the number of people tested. The negative predictive value of rapid HIV tests is so high that negative results are considered conclusive despite the fact that false-negative results can occur in several situations. While the specificity and sensitivity of rapid HIV tests in resource-rich countries is acceptable, there are only limited data about their performance in resource-constrained countries. The challenges of rapid HIV testing in these situations will be discussed.

Original language	English (US)
Title of host publication	Sensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring II; and Biometric Technology for Human Identification IX
DOIs	https://doi.org/10.1117/12.924574
State	Published - 2012
Event	Sensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring II; and Biometric Technology for Human Identification IX - Baltimore, MD, United States Duration: Apr 23 2012 → Apr 25 2012

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	8371
ISSN (Print)	0277-786X

Other

Other	Sensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring II; and Biometric Technology for Human Identification IX
Country/Territory	United States
City	Baltimore, MD
Period	4/23/12 → 4/25/12

Keywords

False negative result
HIV quality assurance testing
Non-B type HIV
Rapid HIV test
Seroconversion
Window period

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1117/12.924574

Cite this

Yogev, R. (2012). Rapid HIV testing for developing countries: The challenge of false-negative tests. In Sensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring II; and Biometric Technology for Human Identification IX Article 83710C (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 8371). https://doi.org/10.1117/12.924574

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Yogev, R 2012, Rapid HIV testing for developing countries: The challenge of false-negative tests. in Sensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring II; and Biometric Technology for Human Identification IX., 83710C, Proceedings of SPIE - The International Society for Optical Engineering, vol. 8371, Sensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring II; and Biometric Technology for Human Identification IX, Baltimore, MD, United States, 4/23/12. https://doi.org/10.1117/12.924574

Rapid HIV testing for developing countries: The challenge of false-negative tests. / Yogev, Ram.
Sensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring II; and Biometric Technology for Human Identification IX. 2012. 83710C (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 8371).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AB - It is a common practice in resource-constrained countries to accept two positive rapid HIV antibody test results as diagnostic for HIV infection. Because these tests are inexpensive and results are obtained quickly, they are recommended by the WHO to "scale-up" HIV testing to increase the number of people tested. The negative predictive value of rapid HIV tests is so high that negative results are considered conclusive despite the fact that false-negative results can occur in several situations. While the specificity and sensitivity of rapid HIV tests in resource-rich countries is acceptable, there are only limited data about their performance in resource-constrained countries. The challenges of rapid HIV testing in these situations will be discussed.

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KW - Non-B type HIV

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KW - Seroconversion

KW - Window period

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Yogev R. Rapid HIV testing for developing countries: The challenge of false-negative tests. In Sensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring II; and Biometric Technology for Human Identification IX. 2012. 83710C. (Proceedings of SPIE - The International Society for Optical Engineering). doi: 10.1117/12.924574

Rapid HIV testing for developing countries: The challenge of false-negative tests

Abstract

Publication series

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Keywords

ASJC Scopus subject areas

UN SDGs

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