Rapid HIV testing for developing countries: The challenge of false-negative tests

Ram Yogev*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

It is a common practice in resource-constrained countries to accept two positive rapid HIV antibody test results as diagnostic for HIV infection. Because these tests are inexpensive and results are obtained quickly, they are recommended by the WHO to "scale-up" HIV testing to increase the number of people tested. The negative predictive value of rapid HIV tests is so high that negative results are considered conclusive despite the fact that false-negative results can occur in several situations. While the specificity and sensitivity of rapid HIV tests in resource-rich countries is acceptable, there are only limited data about their performance in resource-constrained countries. The challenges of rapid HIV testing in these situations will be discussed.

Original languageEnglish (US)
Title of host publicationSensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring II; and Biometric Technology for Human Identification IX
DOIs
StatePublished - Jul 23 2012
EventSensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring II; and Biometric Technology for Human Identification IX - Baltimore, MD, United States
Duration: Apr 23 2012Apr 25 2012

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume8371
ISSN (Print)0277-786X

Other

OtherSensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring II; and Biometric Technology for Human Identification IX
CountryUnited States
CityBaltimore, MD
Period4/23/124/25/12

Keywords

  • False negative result
  • HIV quality assurance testing
  • Non-B type HIV
  • Rapid HIV test
  • Seroconversion
  • Window period

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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