Rapid miniaturized chromatography for Tc-99m IDA agents: Comparison with gel chromatography

A. Michael Zimmer*, Walter Majewski, Stewart M. Spies

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Miniaturized chromatographic systems for determining free pertechnetate and hydrolyzed reduced 99mTc levels in comericial 99mTc-labeled iminodiacetate (IDA) hepatobiliary radio-pharmaceuticals were evaluated and the results compared with gel chromatography column scanning (GCS). Commercial IDA agents were evaluated including 2,6-dimethyl IDA, p-isopropyl IDA, p-butyl IDA, and 2,6-diisopropyl IDA. Of all the chromatography systems evaluated, only Gelman ITLC-SA with 20% NaCl and Gelman ITLC-SG with distilled water correlated with GCS in evaluating free pertechnetate and hydrolyzed reduced 99mTc levels for all IDA radiopharmaceuticals. The miniaturized chromatography procedure, as outlined, is rapid, taking less than 4 min, and can easily be incorporated into the daily quality control program in any nuclear medicine facility.

Original languageEnglish (US)
Pages (from-to)88-91
Number of pages4
JournalEuropean Journal of Nuclear Medicine
Volume7
Issue number2
DOIs
StatePublished - Feb 1 1982

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Rapid miniaturized chromatography for Tc-99m IDA agents: Comparison with gel chromatography'. Together they form a unique fingerprint.

Cite this