Rapid-Onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD)

C. M. Rand; P. P. Patwari; M. S. Carroll; D. E. Weese-Mayer

doi:10.1016/B978-0-12-378610-4.00540-4

Rapid-Onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD)

C. M. Rand^*, P. P. Patwari, M. S. Carroll, D. E. Weese-Mayer

^*Corresponding author for this work

Pediatrics

Research output: Chapter in Book/Report/Conference proceeding › Chapter

5 Scopus citations

Abstract

Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD) is a rare disorder of respiratory control, the endocrine system, and the autonomic nervous system. Affected children typically present between 1.5 and 10 years of age with rapid and significant weight gain. Subsequently, they develop alveolar hypoventilation, autonomic nervous system dysfunction, and, if untreated, cardiorespiratory arrest. Early recognition and conservative management are essential to optimize outcome. With the epidemic of childhood obesity and related sleep-disordered breathing, it is essential that physicians are attuned to children who develop endogenous/pathological obesity and who therefore may be at risk for cardiorespiratory arrest.

Original language	English (US)
Title of host publication	Encyclopedia of Sleep
Publisher	Elsevier Inc
Pages	332-338
Number of pages	7
ISBN (Electronic)	9780123786111
ISBN (Print)	9780123786104
DOIs	https://doi.org/10.1016/B978-0-12-378610-4.00540-4
State	Published - Jan 1 2013

Keywords

Alveolar hypoventilation
Autonomic nervous system
Congenital central hypoventilation syndrome (CCHS)
Diabetes insipidus
Ganglioneuroblastoma
Ganglioneuroma
Hypernatremia
Hyperprolactinemia
Hypothalamic dysfunction
Late-onset central hypoventilation
Obesity
Obstructive sleep apnea
Pupillary dysfunction
Thermoregulatory dysfunction
Tumors of neural crest origin

ASJC Scopus subject areas

Medicine (miscellaneous)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/B978-0-12-378610-4.00540-4

Cite this

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title = "Rapid-Onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD)",

abstract = "Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD) is a rare disorder of respiratory control, the endocrine system, and the autonomic nervous system. Affected children typically present between 1.5 and 10 years of age with rapid and significant weight gain. Subsequently, they develop alveolar hypoventilation, autonomic nervous system dysfunction, and, if untreated, cardiorespiratory arrest. Early recognition and conservative management are essential to optimize outcome. With the epidemic of childhood obesity and related sleep-disordered breathing, it is essential that physicians are attuned to children who develop endogenous/pathological obesity and who therefore may be at risk for cardiorespiratory arrest.",

keywords = "Alveolar hypoventilation, Autonomic nervous system, Congenital central hypoventilation syndrome (CCHS), Diabetes insipidus, Ganglioneuroblastoma, Ganglioneuroma, Hypernatremia, Hyperprolactinemia, Hypothalamic dysfunction, Late-onset central hypoventilation, Obesity, Obstructive sleep apnea, Pupillary dysfunction, Thermoregulatory dysfunction, Tumors of neural crest origin",

author = "Rand, {C. M.} and Patwari, {P. P.} and Carroll, {M. S.} and Weese-Mayer, {D. E.}",

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doi = "10.1016/B978-0-12-378610-4.00540-4",

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AU - Rand, C. M.

AU - Patwari, P. P.

AU - Carroll, M. S.

AU - Weese-Mayer, D. E.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD) is a rare disorder of respiratory control, the endocrine system, and the autonomic nervous system. Affected children typically present between 1.5 and 10 years of age with rapid and significant weight gain. Subsequently, they develop alveolar hypoventilation, autonomic nervous system dysfunction, and, if untreated, cardiorespiratory arrest. Early recognition and conservative management are essential to optimize outcome. With the epidemic of childhood obesity and related sleep-disordered breathing, it is essential that physicians are attuned to children who develop endogenous/pathological obesity and who therefore may be at risk for cardiorespiratory arrest.

AB - Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD) is a rare disorder of respiratory control, the endocrine system, and the autonomic nervous system. Affected children typically present between 1.5 and 10 years of age with rapid and significant weight gain. Subsequently, they develop alveolar hypoventilation, autonomic nervous system dysfunction, and, if untreated, cardiorespiratory arrest. Early recognition and conservative management are essential to optimize outcome. With the epidemic of childhood obesity and related sleep-disordered breathing, it is essential that physicians are attuned to children who develop endogenous/pathological obesity and who therefore may be at risk for cardiorespiratory arrest.

KW - Alveolar hypoventilation

KW - Autonomic nervous system

KW - Congenital central hypoventilation syndrome (CCHS)

KW - Diabetes insipidus

KW - Ganglioneuroblastoma

KW - Ganglioneuroma

KW - Hypernatremia

KW - Hyperprolactinemia

KW - Hypothalamic dysfunction

KW - Late-onset central hypoventilation

KW - Obesity

KW - Obstructive sleep apnea

KW - Pupillary dysfunction

KW - Thermoregulatory dysfunction

KW - Tumors of neural crest origin

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M3 - Chapter

SN - 9780123786104

SP - 332

EP - 338

BT - Encyclopedia of Sleep

PB - Elsevier Inc

ER -

Rapid-Onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD)

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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