Rapid-Onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD)

C. M. Rand*, P. P. Patwari, M. S. Carroll, D. E. Weese-Mayer

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations


Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD) is a rare disorder of respiratory control, the endocrine system, and the autonomic nervous system. Affected children typically present between 1.5 and 10 years of age with rapid and significant weight gain. Subsequently, they develop alveolar hypoventilation, autonomic nervous system dysfunction, and, if untreated, cardiorespiratory arrest. Early recognition and conservative management are essential to optimize outcome. With the epidemic of childhood obesity and related sleep-disordered breathing, it is essential that physicians are attuned to children who develop endogenous/pathological obesity and who therefore may be at risk for cardiorespiratory arrest.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Sleep
PublisherElsevier Inc
Number of pages7
ISBN (Electronic)9780123786111
ISBN (Print)9780123786104
StatePublished - Jan 1 2013


  • Alveolar hypoventilation
  • Autonomic nervous system
  • Congenital central hypoventilation syndrome (CCHS)
  • Diabetes insipidus
  • Ganglioneuroblastoma
  • Ganglioneuroma
  • Hypernatremia
  • Hyperprolactinemia
  • Hypothalamic dysfunction
  • Late-onset central hypoventilation
  • Obesity
  • Obstructive sleep apnea
  • Pupillary dysfunction
  • Thermoregulatory dysfunction
  • Tumors of neural crest origin

ASJC Scopus subject areas

  • Medicine (miscellaneous)


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