Rapid quality control of technetium-99m-tetrofosmin: Comparison of miniaturized and standard chromatography systems

M. C. Geyer*, A. M. Zimmer, William G Spies, S. M. Spies, R. C. Hendel

*Corresponding author for this work

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Objective: In this paper, we evaluate the use of miniaturized ITLC-SG strips (10 cm x 1 cm) with the same solvent system of methylene chloride:acetone (65:35) to reduce the time required to perform the quality control procedure for 99mTc-tetrofosmin. The potential problems inherent in the standard chromatography system were investigated as to the magnitude of their effects on the miniaturized system. Methods: The migration of the radiochemical components of 99mTc-tetrofosmin was evaluated using multiple miniature and standard strip sizes. Following optimization of the miniaturized system, radiochemical purity evaluations were performed simultaneously on 112 99mTc-tetrofosmin preparations using both chromatography systems and the radiochemical purity results compared. Results: Initially, similar migration of radiochemical components was found using both chromatography systems. Results of the radiochemical purity evaluations of 99mTc-tetrofosmin preparations were similar with both chromatography methods, with a mean difference of 1.3% ± 1.5%. Differences in radiochemical purity results between the two chromatography systems were less than 2% in the majority of samples. In no instance was a preparation acceptable with one chromatography system and not acceptable with the other. Conclusion: The results indicate that the miniaturized chromatography system is as effective in evaluating the radiochemical purity of 99mTc-tetrofosmin as the standard quality control procedure, with a substantial reduction in the time required to perform the procedure.

Original languageEnglish (US)
Pages (from-to)186-189
Number of pages4
JournalJournal of Nuclear Medicine Technology
Volume23
Issue number3
StatePublished - Jan 1 1995

Keywords

  • Miniaturized chromatography system
  • Radiochemical purity testing
  • Technetium-99m-tetrofosmin

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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