Abstract
Microneedle devices for transdermal drug delivery have recently become an attractive method to overcome the diffusion-limiting epidermis and effectively transport therapeutics to the body. Here, we demonstrate the fabrication of highly reproducible and completely dissolvable polymer microneedles on flexible water-soluble substrates. These biocompatible microneedles (made by using a soft lithography process known as PRINT) showed efficacy in piercing both murine and human skin samples and delivering a fluorescent drug surrogate to the tissue.
Original language | English (US) |
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Pages (from-to) | 5060-5066 |
Number of pages | 7 |
Journal | Advanced Materials |
Volume | 25 |
Issue number | 36 |
DOIs | |
State | Published - Sep 2013 |
Externally published | Yes |
Keywords
- drug delivery
- microneedles
- microprojections
- soft lithography
ASJC Scopus subject areas
- Mechanics of Materials
- Mechanical Engineering
- General Materials Science