Rapidly-dissolvable microneedle patches via a highly scalable and reproducible soft lithography approach

Katherine A. Moga, Lissett R. Bickford, Robert D. Geil, Stuart S. Dunn, Ashish A. Pandya, Yapei Wang, John H. Fain, Christine F. Archuleta, Adrian T. O'Neill, Joseph M. Desimone*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

83 Scopus citations

Abstract

Microneedle devices for transdermal drug delivery have recently become an attractive method to overcome the diffusion-limiting epidermis and effectively transport therapeutics to the body. Here, we demonstrate the fabrication of highly reproducible and completely dissolvable polymer microneedles on flexible water-soluble substrates. These biocompatible microneedles (made by using a soft lithography process known as PRINT) showed efficacy in piercing both murine and human skin samples and delivering a fluorescent drug surrogate to the tissue.

Original languageEnglish (US)
Pages (from-to)5060-5066
Number of pages7
JournalAdvanced Materials
Volume25
Issue number36
DOIs
StatePublished - Sep 2013
Externally publishedYes

Keywords

  • PRINT
  • drug delivery
  • microneedles
  • microprojections
  • soft lithography

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Fingerprint Dive into the research topics of 'Rapidly-dissolvable microneedle patches via a highly scalable and reproducible soft lithography approach'. Together they form a unique fingerprint.

Cite this