Rare Middle Mediastinal Paraganglioma Mimicking Metastatic Neuroendocrine Tumor

Christopher K. Mehta; Colin T. Gillespie; Xiaoqi Lin; Anjana Yeldandi; Malcolm DeCamp; Ankit Bharat

doi:10.1016/j.athoracsur.2014.09.068

Rare Middle Mediastinal Paraganglioma Mimicking Metastatic Neuroendocrine Tumor

Christopher K. Mehta, Colin T. Gillespie, Xiaoqi Lin, Anjana Yeldandi, Malcolm DeCamp, Ankit Bharat^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Mediastinal paragangliomas are rare neural crest derived tumors that may produce symptoms of excess catecholamine production or mass effect. Paragangliomas can histologically mimic neuroendocrine tumors. Further, both can arise in similar locations. We report a patient who presented with a right upper lobe as well as middle mediastinal lesion. Preoperative biopsy as well as intraoperative frozen section of these lesions failed to distinguish between paraganlioma or neuroendocrine tumor, necessitating a right upper lobectomy and complete mediastinal lymphadenectomy. Final pathology revealed carcinoid tumorlets in the right upper lobe and a middle mediastinal paraganglioma.

Original language	English (US)
Pages (from-to)	702-705
Number of pages	4
Journal	Annals of Thoracic Surgery
Volume	100
Issue number	2
DOIs	https://doi.org/10.1016/j.athoracsur.2014.09.068
State	Published - Aug 1 2015

ASJC Scopus subject areas

Surgery
Pulmonary and Respiratory Medicine
Cardiology and Cardiovascular Medicine

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title = "Rare Middle Mediastinal Paraganglioma Mimicking Metastatic Neuroendocrine Tumor",

abstract = "Mediastinal paragangliomas are rare neural crest derived tumors that may produce symptoms of excess catecholamine production or mass effect. Paragangliomas can histologically mimic neuroendocrine tumors. Further, both can arise in similar locations. We report a patient who presented with a right upper lobe as well as middle mediastinal lesion. Preoperative biopsy as well as intraoperative frozen section of these lesions failed to distinguish between paraganlioma or neuroendocrine tumor, necessitating a right upper lobectomy and complete mediastinal lymphadenectomy. Final pathology revealed carcinoid tumorlets in the right upper lobe and a middle mediastinal paraganglioma.",

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AU - Mehta, Christopher K.

AU - Gillespie, Colin T.

AU - Lin, Xiaoqi

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AU - DeCamp, Malcolm

AU - Bharat, Ankit

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AB - Mediastinal paragangliomas are rare neural crest derived tumors that may produce symptoms of excess catecholamine production or mass effect. Paragangliomas can histologically mimic neuroendocrine tumors. Further, both can arise in similar locations. We report a patient who presented with a right upper lobe as well as middle mediastinal lesion. Preoperative biopsy as well as intraoperative frozen section of these lesions failed to distinguish between paraganlioma or neuroendocrine tumor, necessitating a right upper lobectomy and complete mediastinal lymphadenectomy. Final pathology revealed carcinoid tumorlets in the right upper lobe and a middle mediastinal paraganglioma.

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Rare Middle Mediastinal Paraganglioma Mimicking Metastatic Neuroendocrine Tumor

Abstract

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