Rate of change in serum prostate specific antigen levels as a method for prostate cancer detection

D. S. Smith*, W. J. Catalona

*Corresponding author for this work

Research output: Contribution to journalEditorialpeer-review

145 Scopus citations

Abstract

To examine prospectively the usefulness of measurement of rate of change in serum prostate specific antigen levels (PSA slope) in detecting prostate cancer in a PSA-based prostate cancer screening study, we evaluated 982 serially screened men whose initial screening was negative for cancer. All men had at least 1 PSA value greater than 4.0 ng./ml. and all ultimately underwent prostatic biopsy. For those who entered the study with normal PSA levels, a PSA slope cutoff point of 0.75 ng./ml. per year or more maximized sensitivity and specificity for predicting cancer (odds ratio 7.20, 95% confidence interval 4.52 to 11.47). This cutoff point was most predictive for men 70 years old or younger. For men who entered the study with elevated PSA levels (greater than 4.0 ng./ml.) a lower PSA slope cutoff point (0.4 ng./ml. per year or more) maximized sensitivity and specificity for predicting cancer (odds ratio 2.73, 95% confidence interval 1.82 to 4.07). We conclude that PSA slope is useful for serial prostate cancer screening, although its predictive value varies with patient age and initial PSA level.

Original languageEnglish (US)
Pages (from-to)1163-1167
Number of pages5
JournalJournal of Urology
Volume152
Issue number4
DOIs
StatePublished - 1994

Keywords

  • antigens, neoplasm
  • prostatic neoplasms

ASJC Scopus subject areas

  • Urology

Fingerprint Dive into the research topics of 'Rate of change in serum prostate specific antigen levels as a method for prostate cancer detection'. Together they form a unique fingerprint.

Cite this