Rate of Patch Testing Induced Anaphylaxis

Karishma Daftary, Andrew Scheman, Heidi Bai, Ghazal Ghafari, Walter Liszewski*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: Although allergic contact dermatitis is a type IV hypersensitivity reaction, type I hypersensitivity reactions, such as anaphylaxis, have been reported during patch testing. Objective: The aim of this study was to identify reported cases of anaphylaxis from patch testing and estimate its rate. Methods: A literature review was conducted on PubMed to identify previously reported cases of anaphylaxis after patch testing and suspected allergens. In addition, a survey was distributed to expert patch testing dermatologists to determine the rate of anaphylaxis after patch testing. Results: Three anaphylaxis cases due to patch testing were found in the literature. Twenty-seven of 36 expert patch testers completed the survey for a 75% response rate. These dermatologists have tested an estimated 201,720 patients in their combined careers. From them, 2 cases of patch test anaphylaxis were reported. The rate of anaphylaxis from patch testing was calculated to be 1 in 100,860 tests among our cohort. Conclusions: Patch testing induced anaphylaxis is rare and may be more likely in patients with a history of anaphylaxis. Although rare, dermatologists should have a management plan in place.

Original languageEnglish (US)
Pages (from-to)33-35
Number of pages3
Issue number1
StatePublished - Feb 1 2023

ASJC Scopus subject areas

  • Dermatology
  • Immunology and Allergy


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