Rate of Risk Factors for and Interventions to Reduce Hospital Readmission in Patients With Inflammatory Bowel Diseases

Nghia H. Nguyen, Jejo Koola, Parambir S. Dulai, Larry J. Prokop, William J. Sandborn, Siddharth Singh*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Background & Aims: We investigated 30- and 90-day rates and causes of, risk factors for, and interventions to reduce hospital readmission in patients who received medical treatment for inflammatory bowel diseases (IBD). Methods: We performed a systematic search of publications through July 1, 2018 for studies of rates of hospital readmission and associated causes and risk factors in patients who received medical treatments for IBD. Our final analysis included 17 cohort studies (6324 patients) of hospitalized adults with IBD who had received medical treatment, along with reported readmission rates with detailed chart review. We performed random effects meta-analysis to estimate 30- and 90-day rates of readmission and identified causes and risk factors associated with readmission. We also performed qualitative analyses of studies that focused on interventions to reduce readmission. Results: Overall, the 30-day rate of readmission was 18.1% (95% CI, 14.4–22.4) and the 90-day rate was 26.0% (95% CI, 22.7–29.6). On meta-regression, studies with higher proportions of patients with ulcerative colitis than Crohn's disease reported higher risks for readmission. Most common reasons for readmission were IBD flare, infection, or complications from unplanned surgeries during hospitalizations. Consistent risk factors for 30-day readmission were admission for pain control (odds ratio [OR], 2.27; 95% CI, 1.69–3.03), need for total parenteral nutrition on discharge (OR, 2.13; 95% CI, 1.36–3.35), and prior or unplanned surgery during admission (OR, 3.11; 95% CI, 2.27–4.25). Only 1 study focused on interventions (specialized inpatient IBD service) to reduce risk of readmission. Conclusions: Overall 30- and 90-day rates of readmission for patients who received medical treatment for IBD are 18.1% and 26.0%, respectively. IBD flares and infections are common reasons for readmission, and inadequate pain control and need for parenteral nutrition were common risk factors. Interventional studies to reduce risk of readmission are needed.

Original languageEnglish (US)
Pages (from-to)1939-1948.e7
JournalClinical Gastroenterology and Hepatology
Issue number9
StatePublished - Aug 2020
Externally publishedYes


  • Burden
  • CD
  • Population Health
  • UC
  • Value-Based Care

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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