Rational design of silicon structures for optically controlled multiscale biointerfaces

Yuanwen Jiang; Xiaojian Li; Bing Liu; Jaeseok Yi; Yin Fang; Fengyuan Shi; Xiang Gao; Edward Sudzilovsky; Ramya Parameswaran; Kelliann Koehler; Vishnu Nair; Jiping Yue; Kuang Hua Guo; Yin Fang; Hsiu Ming Tsai; George Freyermuth; Raymond C.S. Wong; Chien Min Kao; Chin Tu Chen; Alan W. Nicholls; Xiaoyang Wu; Gordon M.G. Shepherd; Bozhi Tian

doi:10.1038/s41551-018-0230-1

Rational design of silicon structures for optically controlled multiscale biointerfaces

Yuanwen Jiang, Xiaojian Li, Bing Liu, Jaeseok Yi, Yin Fang, Fengyuan Shi, Xiang Gao, Edward Sudzilovsky, Ramya Parameswaran, Kelliann Koehler, Vishnu Nair, Jiping Yue, Kuang Hua Guo, Yin Fang, Hsiu Ming Tsai, George Freyermuth, Raymond C.S. Wong, Chien Min Kao, Chin Tu Chen, Alan W. NichollsXiaoyang Wu, Gordon M.G. Shepherd, Bozhi Tian^*

^*Corresponding author for this work

Neuroscience

Research output: Contribution to journal › Article › peer-review

207 Scopus citations

Abstract

Silicon-based materials have been widely used in biological applications. However, remotely controlled and interconnect-free silicon configurations have been rarely explored, because of limited fundamental understanding of the complex physicochemical processes that occur at interfaces between silicon and biological materials. Here, we describe rational design principles, guided by biology, for establishing intracellular, intercellular and extracellular silicon-based interfaces, where the silicon and the biological targets have matched properties. We focused on light-induced processes at these interfaces, and developed a set of matrices to quantify and differentiate the capacitive, Faradaic and thermal outputs from about 30 different silicon materials in saline. We show that these interfaces are useful for the light-controlled non-genetic modulation of intracellular calcium dynamics, of cytoskeletal structures and transport, of cellular excitability, of neurotransmitter release from brain slices and of brain activity in vivo.

Original language	English (US)
Pages (from-to)	508-521
Number of pages	14
Journal	Nature Biomedical Engineering
Volume	2
Issue number	7
DOIs	https://doi.org/10.1038/s41551-018-0230-1
State	Published - Jul 1 2018

Funding

This work is supported by the Air Force Office of Scientific Research (AFOSR FA9550-14-1-0175, FA9550-15-1-0285), the National Science Foundation (NSF CAREER, DMR-1254637; NSF MRSEC, DMR 1420709), the Searle Scholars Foundation and the National Institutes of Health (NIH NS101488, and NS061963). This work made use of the Japan Electron Optics Laboratory (JEOL) JEM-ARM200CF and JEOL JEM-3010 TEM in the Electron Microscopy Service of the Research Resources Center at the University of Illinois at Chicago (UIC). The acquisition of the UIC JEOL JEM-ARM200CF was supported by a MRI-R2 grant from the National Science Foundation (DMR-0959470). The animal imaging work conducted at the Integrated Small Animal Imaging Research Resource (iSAIRR) at the University of Chicago was supported in part by funding provided by the Virginia and D. K. Ludwig Fund for Cancer Research via the Imaging Research Institute in the Biological Sciences Division, by the University of Chicago Comprehensive Cancer Center including an NIH grant P30 CA14599, and by the Department of Radiology. Part of the schematic in Fig. 5c was generated from a three-dimensional anatomy software purchased from https://biosphera.org. The authors thank L. Yu, V. Sharapov, S. Patel, Y. Chen, Q. Guo and J. Jureller for providing technical support.

ASJC Scopus subject areas

Biotechnology
Bioengineering
Medicine (miscellaneous)
Biomedical Engineering
Computer Science Applications

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Jiang, Y., Li, X., Liu, B., Yi, J., Fang, Y., Shi, F., Gao, X., Sudzilovsky, E., Parameswaran, R., Koehler, K., Nair, V., Yue, J., Guo, K. H., Fang, Y., Tsai, H. M., Freyermuth, G., Wong, R. C. S., Kao, C. M., Chen, C. T., ... Tian, B. (2018). Rational design of silicon structures for optically controlled multiscale biointerfaces. Nature Biomedical Engineering, 2(7), 508-521. https://doi.org/10.1038/s41551-018-0230-1

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abstract = "Silicon-based materials have been widely used in biological applications. However, remotely controlled and interconnect-free silicon configurations have been rarely explored, because of limited fundamental understanding of the complex physicochemical processes that occur at interfaces between silicon and biological materials. Here, we describe rational design principles, guided by biology, for establishing intracellular, intercellular and extracellular silicon-based interfaces, where the silicon and the biological targets have matched properties. We focused on light-induced processes at these interfaces, and developed a set of matrices to quantify and differentiate the capacitive, Faradaic and thermal outputs from about 30 different silicon materials in saline. We show that these interfaces are useful for the light-controlled non-genetic modulation of intracellular calcium dynamics, of cytoskeletal structures and transport, of cellular excitability, of neurotransmitter release from brain slices and of brain activity in vivo.",

author = "Yuanwen Jiang and Xiaojian Li and Bing Liu and Jaeseok Yi and Yin Fang and Fengyuan Shi and Xiang Gao and Edward Sudzilovsky and Ramya Parameswaran and Kelliann Koehler and Vishnu Nair and Jiping Yue and Guo, \{Kuang Hua\} and Yin Fang and Tsai, \{Hsiu Ming\} and George Freyermuth and Wong, \{Raymond C.S.\} and Kao, \{Chien Min\} and Chen, \{Chin Tu\} and Nicholls, \{Alan W.\} and Xiaoyang Wu and Shepherd, \{Gordon M.G.\} and Bozhi Tian",

note = "Publisher Copyright: {\textcopyright} 2018 The Author(s) 2018, under exclusive licence to Macmillan Publishers Ltd, part of Springer Nature.",

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month = jul,

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Jiang, Y, Li, X, Liu, B, Yi, J, Fang, Y, Shi, F, Gao, X, Sudzilovsky, E, Parameswaran, R, Koehler, K, Nair, V, Yue, J, Guo, KH, Fang, Y, Tsai, HM, Freyermuth, G, Wong, RCS, Kao, CM, Chen, CT, Nicholls, AW, Wu, X, Shepherd, GMG & Tian, B 2018, 'Rational design of silicon structures for optically controlled multiscale biointerfaces', Nature Biomedical Engineering, vol. 2, no. 7, pp. 508-521. https://doi.org/10.1038/s41551-018-0230-1

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AU - Yue, Jiping

AU - Guo, Kuang Hua

AU - Fang, Yin

AU - Tsai, Hsiu Ming

AU - Freyermuth, George

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AU - Chen, Chin Tu

AU - Nicholls, Alan W.

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AU - Tian, Bozhi

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Rational design of silicon structures for optically controlled multiscale biointerfaces

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