Rationale and design of PROACT Xa: A randomized, multicenter, open-label, clinical trial to evaluate the efficacy and safety of apixaban versus warfarin in patients with a mechanical On-X Aortic Heart Valve

Oliver K. Jawitz*, Tracy Y. Wang, Renato D. Lopes, Alma Chavez, Brittanny Boyer, Hwasoon Kim, Kevin J. Anstrom, Richard C. Becker, Eugene Blackstone, Marc Ruel, Vinod H. Thourani, John D. Puskas, Marc W. Gerdisch, Douglas Johnston, Scott Capps, John H. Alexander, Lars G. Svensson

*Corresponding author for this work

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Medicine and Dentistry

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Pharmacology, Toxicology and Pharmaceutical Science