Vers une approche physiopathologique des troubles de l'ejaculation

Translated title of the contribution: Rationale for a pathophysiological approach of ejaculatory disturbances

F. Giuliano*, K. Mac Kenna, S. Droupy, O. Rampin, V. Izard, G. Benoit, A. Jardin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Seminal emission and sperm expulsion are under the control of both the sympathetic and parasympathetic outflows and also of the somatic innervation conveyed by the pudendal nerve. The 2 phases of ejaculation are reflexive with the reflexes handled at the thoraco-lumbar and sacral levels of the spinal cord. Such a spinal organization remains widely unknown. The role of various peripheral neurotransmitters has been evidenced including norepinephrine and acetylcholine and also peptidergic, purinergic i.e. ATP and nitric oxide. Stimulation of the seminal tract afferents play a crucial in the onset of ejaculatory mechanisms. Except for the dorsal nerve of the penis, there is a lack of information concerning these afferents. Several supraspinal centers i.e. hypothalamus, medial amygdala, pons and nucleus paragigantocellularis exert descending and ascending inhibitory and excitatory influences on spinal nuclei controlling emission and expulsion of sperm. Central neurotransmission responsible for this supraspinal control could involve serotonin, oxytocin and norepinephrine. In the light of the available anatomical and neurophysiological data, pathophysiological aspects of ejaculatory disorders are luther discussed. Premature ejaculation could be related to a periheral and central hypersentivity. Most of the other ejaculation abnormalities are likely mainly related to an impairment of the central mechanisms.

Translated title of the contributionRationale for a pathophysiological approach of ejaculatory disturbances
Original languageFrench
Pages (from-to)226-246
Number of pages21
JournalAndrologie
Volume9
Issue number2
DOIs
StatePublished - Jun 1999

Keywords

  • Central nervous system
  • Ejaculation
  • Emission
  • Neurophysiology
  • Premature ejaculation

ASJC Scopus subject areas

  • Reproductive Medicine
  • Urology

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