RAUWOLFIA DERIVATIVES AND BREAST CANCER. A Case/control Study in Olmsted County, Minnesota

W. Michael O'Fallon*, Darwin R. Labarthe, Leonard T. Kurland

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

In response to three reports of an association between rauwolfia derivatives and breast cancer, a case/control study was undertaken in Olmsted County, Minnesota. Comparison of a cohort of women with breast cancer to an age-matched cohort of women with cholelithiasis failed to show any meaningful differences in the two groups except with respect to a history of hypertension. The rates of use of rauwolfia derivatives by hypertensive cases and controls were identical-which, along with other considerations, leads to the conclusion that an association between the use of rauwolfia derivatives and breast cancer is unlikely.

Original languageEnglish (US)
Pages (from-to)292-296
Number of pages5
JournalThe Lancet
Volume306
Issue number7929
DOIs
StatePublished - Aug 16 1975

ASJC Scopus subject areas

  • Medicine(all)

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