Re-irradiation and external hyperthermia in locally advanced, radiation recurrent, hormone refractory prostate cancer: A preliminary report

J. A. Kalapurakal*, B. B. Mittal, V. Sathiaseelan

*Corresponding author for this work

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The purpose of this report is to present the preliminary results of re-irradiation and external hyperthermia in patients with locally advanced, previously irradiated, hormone refractory prostate cancer. Three consecutive patients with symptomatic, locally advanced, previously irradiated and hormone refractory prostate cancer were treated with further irradiation (30.6-50 Gy) and external hyperthermia (5-8 treatments). All patients had complete resolution of symptoms lasting for 12-24 months. Significant tumour shrinkage, including complete tumour response, was demonstrated by CT and endoscopy. In one case, at 2 years after re-treatment, there is continued tumour regression and bone regeneration in the pelvis. Two patients had local control of tumour, which continued until most recent follow-up at 12 months and more than 24 months, respectively. Another case developed local recurrence at 17 months. At most recent follow-up, no patient has experienced significant treatment-related side effects. In these patients with no other therapeutic alternatives, re-irradiation and hyperthermia can provide durable tumour response for more than a year, resulting in significant improvement in quality of life. Further clinical studies are warranted.

Original languageEnglish (US)
Pages (from-to)745-751
Number of pages7
JournalBritish Journal of Radiology
Volume74
Issue number884
DOIs
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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