Reactive oxygen species-dependent signaling regulates cancer

Frank Weinberg; Navdeep S. Chandel

doi:10.1007/s00018-009-0099-y

Reactive oxygen species-dependent signaling regulates cancer

Frank Weinberg, Navdeep S. Chandel

Medicine, Pulmonary Division

Research output: Contribution to journal › Review article › peer-review

238 Scopus citations

Abstract

Historically, it has been assumed that oxidative stress contributes to tumor initiation and progression solely by inducing genomic instability. Recent studies indicate that reactive oxygen species are upregulated in tumors and can lead to aberrant induction of signaling networks that cause tumorigenesis and metastasis. Here we review the role of redox-dependent signaling pathways and transcription factors that regulate tumorigenesis.

Original language	English (US)
Pages (from-to)	3663-3673
Number of pages	11
Journal	Cellular and Molecular Life Sciences
Volume	66
Issue number	23
DOIs	https://doi.org/10.1007/s00018-009-0099-y
State	Published - Jan 2009

Funding

This work was supported by NIH Grant R01CA123067-03 as well as the LUNGevity Foundation and a Consortium of Independent Lung Health Organizations convened by the Respiratory Health Association of Metropolitan Chicago to N.S.C.

Keywords

HIF
Metastasis
Mitochondria
NADPH oxidase
ROS
Tumorigenesis

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Molecular Medicine
Molecular Biology
Cell Biology
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00018-009-0099-y

Cite this

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title = "Reactive oxygen species-dependent signaling regulates cancer",

abstract = "Historically, it has been assumed that oxidative stress contributes to tumor initiation and progression solely by inducing genomic instability. Recent studies indicate that reactive oxygen species are upregulated in tumors and can lead to aberrant induction of signaling networks that cause tumorigenesis and metastasis. Here we review the role of redox-dependent signaling pathways and transcription factors that regulate tumorigenesis.",

keywords = "HIF, Metastasis, Mitochondria, NADPH oxidase, ROS, Tumorigenesis",

author = "Frank Weinberg and Chandel, {Navdeep S.}",

note = "Funding Information: This work was supported by NIH Grant R01CA123067-03 as well as the LUNGevity Foundation and a Consortium of Independent Lung Health Organizations convened by the Respiratory Health Association of Metropolitan Chicago to N.S.C.",

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language = "English (US)",

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AU - Weinberg, Frank

AU - Chandel, Navdeep S.

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PY - 2009/1

Y1 - 2009/1

N2 - Historically, it has been assumed that oxidative stress contributes to tumor initiation and progression solely by inducing genomic instability. Recent studies indicate that reactive oxygen species are upregulated in tumors and can lead to aberrant induction of signaling networks that cause tumorigenesis and metastasis. Here we review the role of redox-dependent signaling pathways and transcription factors that regulate tumorigenesis.

AB - Historically, it has been assumed that oxidative stress contributes to tumor initiation and progression solely by inducing genomic instability. Recent studies indicate that reactive oxygen species are upregulated in tumors and can lead to aberrant induction of signaling networks that cause tumorigenesis and metastasis. Here we review the role of redox-dependent signaling pathways and transcription factors that regulate tumorigenesis.

KW - HIF

KW - Metastasis

KW - Mitochondria

KW - NADPH oxidase

KW - ROS

KW - Tumorigenesis

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JO - Cellular and Molecular Life Sciences

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ER -

Reactive oxygen species-dependent signaling regulates cancer

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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