Reactive oxygen species-dependent signaling regulates cancer

Frank Weinberg, Navdeep S. Chandel

Research output: Contribution to journalReview articlepeer-review

192 Scopus citations

Abstract

Historically, it has been assumed that oxidative stress contributes to tumor initiation and progression solely by inducing genomic instability. Recent studies indicate that reactive oxygen species are upregulated in tumors and can lead to aberrant induction of signaling networks that cause tumorigenesis and metastasis. Here we review the role of redox-dependent signaling pathways and transcription factors that regulate tumorigenesis.

Original languageEnglish (US)
Pages (from-to)3663-3673
Number of pages11
JournalCellular and Molecular Life Sciences
Volume66
Issue number23
DOIs
StatePublished - Jan 2009

Keywords

  • HIF
  • Metastasis
  • Mitochondria
  • NADPH oxidase
  • ROS
  • Tumorigenesis

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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