TY - JOUR
T1 - Reactive Oxygen Species in Cancer
T2 - A Dance with the Devil
AU - Schumacker, Paul T.
PY - 2015/2/9
Y1 - 2015/2/9
N2 - Reactive oxygen species (ROS) can initiate cancer, but oxidant generation in tumors leaves them vulnerable to further stresses. In this issue of Cancer Cell, Harris and colleagues show that augmenting oxidant stress in normal cells limits tumor initiation and progression. Hence, strategic targeting of antioxidant systems may undermine survival of new tumor cells. Reactive oxygen species (ROS) can initiate cancer, but oxidant generation in tumors leaves them vulnerable to further stresses. In this issue of Cancer Cell, Harris and colleagues show that augmenting oxidant stress in normal cells limits tumor initiation and progression. Hence, strategic targeting of antioxidant systems may undermine survival of new tumor cells.
AB - Reactive oxygen species (ROS) can initiate cancer, but oxidant generation in tumors leaves them vulnerable to further stresses. In this issue of Cancer Cell, Harris and colleagues show that augmenting oxidant stress in normal cells limits tumor initiation and progression. Hence, strategic targeting of antioxidant systems may undermine survival of new tumor cells. Reactive oxygen species (ROS) can initiate cancer, but oxidant generation in tumors leaves them vulnerable to further stresses. In this issue of Cancer Cell, Harris and colleagues show that augmenting oxidant stress in normal cells limits tumor initiation and progression. Hence, strategic targeting of antioxidant systems may undermine survival of new tumor cells.
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U2 - 10.1016/j.ccell.2015.01.007
DO - 10.1016/j.ccell.2015.01.007
M3 - Short survey
C2 - 25670075
AN - SCOPUS:84922763809
VL - 27
SP - 156
EP - 157
JO - Cancer Cell
JF - Cancer Cell
SN - 1535-6108
IS - 2
ER -