Reactive Oxygen Species in Cancer: A Dance with the Devil

Paul T. Schumacker*

*Corresponding author for this work

Research output: Contribution to journalShort survey

173 Scopus citations

Abstract

Reactive oxygen species (ROS) can initiate cancer, but oxidant generation in tumors leaves them vulnerable to further stresses. In this issue of Cancer Cell, Harris and colleagues show that augmenting oxidant stress in normal cells limits tumor initiation and progression. Hence, strategic targeting of antioxidant systems may undermine survival of new tumor cells. Reactive oxygen species (ROS) can initiate cancer, but oxidant generation in tumors leaves them vulnerable to further stresses. In this issue of Cancer Cell, Harris and colleagues show that augmenting oxidant stress in normal cells limits tumor initiation and progression. Hence, strategic targeting of antioxidant systems may undermine survival of new tumor cells.

Original languageEnglish (US)
Pages (from-to)156-157
Number of pages2
JournalCancer Cell
Volume27
Issue number2
DOIs
StatePublished - Feb 9 2015

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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