TY - JOUR
T1 - Reactive Oxygen Species Regulate T Cell Immune Response in the Tumor Microenvironment
AU - Chen, Xinfeng
AU - Song, Mengjia
AU - Zhang, Bin
AU - Zhang, Yi
N1 - Funding Information:
This study was supported by grants fromtheNationalNatural Science Foundation of China (no. 81171986 and no. 81271815), Research Grant from the Ministry of Public Health (no. 201501004), the Basic and Advanced Technology Research Foundation from Science and Technology Department of Henan Province (no. 112300410153 and no. 122300410155), Funds for Creative Research Team of Henan Province, Creative Research TeamofHigher Education ofHenan Province, and International Cooperative Research of Henan Province
Publisher Copyright:
© 2016 Xinfeng Chen et al.
PY - 2016
Y1 - 2016
N2 - Reactive oxygen species (ROS) produced by cellular metabolism play an important role as signaling messengers in immune system. ROS elevated in the tumor microenvironment are associated with tumor-induced immunosuppression. T cell-based therapy has been recently approved to be effective for cancer treatment. However, T cells often become dysfunctional after reaching the tumor site. It has been reported that ROS participate extensively in T cells activation, apoptosis, and hyporesponsiveness. The sensitivity of T cells to ROS varies among different subsets. ROS can be regulated by cytokines, amino acid metabolism, and enzymatic activity. Immunosuppressive cells accumulate in the tumor microenvironment and induce apoptosis and functional suppression of T cells by producing ROS. Thus, modulating the level of ROS may be important to prolong survival of T cells and enhance their antitumor function. Combining T cell-based therapy with antioxidant treatment such as administration of ROS scavenger should be considered as a promising strategy in cancer treatment, aiming to improve antitumor T cells immunity.
AB - Reactive oxygen species (ROS) produced by cellular metabolism play an important role as signaling messengers in immune system. ROS elevated in the tumor microenvironment are associated with tumor-induced immunosuppression. T cell-based therapy has been recently approved to be effective for cancer treatment. However, T cells often become dysfunctional after reaching the tumor site. It has been reported that ROS participate extensively in T cells activation, apoptosis, and hyporesponsiveness. The sensitivity of T cells to ROS varies among different subsets. ROS can be regulated by cytokines, amino acid metabolism, and enzymatic activity. Immunosuppressive cells accumulate in the tumor microenvironment and induce apoptosis and functional suppression of T cells by producing ROS. Thus, modulating the level of ROS may be important to prolong survival of T cells and enhance their antitumor function. Combining T cell-based therapy with antioxidant treatment such as administration of ROS scavenger should be considered as a promising strategy in cancer treatment, aiming to improve antitumor T cells immunity.
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U2 - 10.1155/2016/1580967
DO - 10.1155/2016/1580967
M3 - Review article
C2 - 27547291
AN - SCOPUS:84982126256
VL - 2016
JO - Oxidative Medicine and Cellular Longevity
JF - Oxidative Medicine and Cellular Longevity
SN - 1942-0900
M1 - 1580967
ER -