TY - JOUR
T1 - Reactive Porous Polymers for Detoxification of a Chemical Warfare Agent Simulant
AU - Jung, Dahee
AU - Das, Pradipta
AU - Atilgan, Ahmet
AU - Li, Peng
AU - Hupp, Joseph T.
AU - Islamoglu, Timur
AU - Kalow, Julia A.
AU - Farha, Omar K.
N1 - Funding Information:
The authors acknowledge the support from the Defense Threat Reduction Agency under Award Number HDTRA1-19-1-0010. This work made use of the Integrated Molecular Structure Education and Research Center (IMSERC) NMR facility at Northwestern University, which has received support from NSF CHE-1048773, the Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-2025633) and Northwestern University. We also acknowledge the EPIC facility of Northwestern University’s NUANCE Center, which has received support from the SHyNE Resource (NSF ECCS-2025633), the IIN, and Northwestern's MRSEC program (NSF DMR-1720139). The authors thank Yijing Chen for the acquisition of ζ-potential measurements and Dr. Anna Yang and Dr. Louis R. Redfern for helpful discussions.
Publisher Copyright:
© 2020 Macromolecules. All rights reserved.
PY - 2020/11/10
Y1 - 2020/11/10
N2 - While polymers of intrinsic microporosity (PIMs) possess appealing features such as high surface area, good solubility, and tailorable functional groups on the polymer backbone, their ability to decompose toxic chemicals has not been explored. Here, an archetypal PIM, PIM-1, has been modified with various nucleophiles and investigated as a reactive, porous, and processable polymer for degradation of a chemical warfare agent (CWA) simulant, dimethyl 4-nitrophenylphosphonate (DMNP). By quantitatively comparing the reactivity of multiple small-molecule nucleophile scaffolds as organophosphate scavengers, we identified potential nucleophiles to incorporate into PIMs. Among the nucleophiles carboxylic acid, amidoxime, and amide, the amidoxime-functionalized PIMs exhibited the most promising performance in detoxifying DMNP. Modified PIMs showed permanent porosity, which is crucial for accessing the reactive groups residing in the pores. With this study, we provide new insight into PIMs as a reactive material for the decontamination of CWAs with their potential use in protective gear such as suits and masks.
AB - While polymers of intrinsic microporosity (PIMs) possess appealing features such as high surface area, good solubility, and tailorable functional groups on the polymer backbone, their ability to decompose toxic chemicals has not been explored. Here, an archetypal PIM, PIM-1, has been modified with various nucleophiles and investigated as a reactive, porous, and processable polymer for degradation of a chemical warfare agent (CWA) simulant, dimethyl 4-nitrophenylphosphonate (DMNP). By quantitatively comparing the reactivity of multiple small-molecule nucleophile scaffolds as organophosphate scavengers, we identified potential nucleophiles to incorporate into PIMs. Among the nucleophiles carboxylic acid, amidoxime, and amide, the amidoxime-functionalized PIMs exhibited the most promising performance in detoxifying DMNP. Modified PIMs showed permanent porosity, which is crucial for accessing the reactive groups residing in the pores. With this study, we provide new insight into PIMs as a reactive material for the decontamination of CWAs with their potential use in protective gear such as suits and masks.
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U2 - 10.1021/acs.chemmater.0c03160
DO - 10.1021/acs.chemmater.0c03160
M3 - Article
AN - SCOPUS:85095723098
SN - 0897-4756
VL - 32
SP - 9299
EP - 9306
JO - Chemistry of Materials
JF - Chemistry of Materials
IS - 21
ER -
