Rearrangement of chromatin domains in cancer and development

J. L. Roti Roti, D. Gius, R. P. VanderWaal, M. Xu

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Both the accomplishment of developmental programs and neoplastic transformation are linked to changes in the long-range organization of chromatin, in particular, DNA loop domains. The development of new methods that allow the study of interactions between the bases of DNA loops and the proteins of the nuclear matrix will help our understanding of the molecular mechanisms in such changes. These methods should also allow the establishment of a fingerprint "signature" for many cancers that may serve for diagnostic purposes.

Original languageEnglish (US)
Pages (from-to)54-60
Number of pages7
JournalJournal of Cellular Biochemistry
Volume80
Issue numberSUPPL. 35
StatePublished - Dec 1 2000

Keywords

  • Cancer
  • DNA loop domains
  • Development
  • Fingerprinting
  • Nuclear matrix

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Roti Roti, J. L., Gius, D., VanderWaal, R. P., & Xu, M. (2000). Rearrangement of chromatin domains in cancer and development. Journal of Cellular Biochemistry, 80(SUPPL. 35), 54-60.