Reasons for Hospitalization and In-Hospital Mortality in Adults with Dermatomyositis and Polymyositis

Mavi Rivera Pavon*, Juan Eduardo Sanchez, Jay Pescatore, Ehizogie Edigin, Carrie Richardson, Augustine Manadan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective Dermatomyositis (DM) and polymyositis (PM) are systemic autoimmune diseases that have been associated with high in-hospital mortality (IHM). The aim of this study was to use the National Inpatient Sample (NIS), a large US population database, to determine the reasons for hospitalization and IHM in patients with DM and PM. Methods We conducted a medical records review of adult DM/PM hospitalizations in 2016 and 2017 in acute care hospitals across the United States using the NIS. The reasons for IHM and reasons for hospitalization were divided into 19 broad categories based on their principal International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10) diagnosis. Results A total of 27,140 hospitalizations carried either a principal or secondary ICD-10 code for DM or PM. The main reasons for hospitalization were rheumatologic (22%, n = 6085), cardiovascular (15%, n = 3945), infectious (13%, n = 3515), respiratory (12%, n = 3170), and gastrointestinal, (8%, n = 2150). A total of 3.5% of all patients experienced IHM. Infectious (34%, n = 325), respiratory (23%, n = 215), and cardiovascular (15%, n = 140) diagnoses were the most common reasons for IHM. Sepsis ICD-10 A41.9 was the most frequent specific principal diagnosis for both hospitalizations and IHM. Conclusions Our analysis demonstrated that in the NIS the most common reasons for hospitalization in patients with DM/PM were rheumatologic diagnoses. However, IHM in these patients was most frequently from infectious diagnoses, highlighting the need for increased attention to infectious complications in these patients.

Original languageEnglish (US)
Pages (from-to)433-439
Number of pages7
JournalJournal of Clinical Rheumatology
Issue number2
StatePublished - Mar 1 2022


  • dermatomyositis
  • hospitalization
  • mortality
  • polymyositis

ASJC Scopus subject areas

  • Rheumatology


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