Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid

John T. Whitteck; Weijuan Ni; Benjamin M. Griffin; Andrew C. Eliot; Paul M. Thomas; Neil L. Kelleher; William W. Metcalf; Wilfred A. Van Der Donk

doi:10.1002/anie.200703810

Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid

John T. Whitteck^*, Weijuan Ni, Benjamin M. Griffin, Andrew C. Eliot, Paul M. Thomas, Neil L. Kelleher, William W. Metcalf, Wilfred A. Van Der Donk

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

(Chemical Equation Presented) Third time's the charm! The structure of the phosphonate antibiotic A53868, first isolated in 1983 from Streptomyces luridus, has proven quite elusive. Originally reported as 1 and later revised to 2, the actual structure of the compound is the unusual dehydro aminophosphonic acid 3.

Original language	English (US)
Pages (from-to)	9089-9092
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	46
Issue number	47
DOIs	https://doi.org/10.1002/anie.200703810
State	Published - 2007

Keywords

Antibiotics
Biosynthesis
NMR spectroscopy
Phosphonate
Structure elucidation

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.200703810

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title = "Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid",

abstract = "(Chemical Equation Presented) Third time's the charm! The structure of the phosphonate antibiotic A53868, first isolated in 1983 from Streptomyces luridus, has proven quite elusive. Originally reported as 1 and later revised to 2, the actual structure of the compound is the unusual dehydro aminophosphonic acid 3.",

keywords = "Antibiotics, Biosynthesis, NMR spectroscopy, Phosphonate, Structure elucidation",

author = "Whitteck, {John T.} and Weijuan Ni and Griffin, {Benjamin M.} and Eliot, {Andrew C.} and Thomas, {Paul M.} and Kelleher, {Neil L.} and Metcalf, {William W.} and {Van Der Donk}, {Wilfred A.}",

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Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid. / Whitteck, John T.; Ni, Weijuan; Griffin, Benjamin M.; Eliot, Andrew C.; Thomas, Paul M.; Kelleher, Neil L.; Metcalf, William W.; Van Der Donk, Wilfred A.

In: Angewandte Chemie - International Edition, Vol. 46, No. 47, 2007, p. 9089-9092.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid

AU - Whitteck, John T.

AU - Ni, Weijuan

AU - Griffin, Benjamin M.

AU - Eliot, Andrew C.

AU - Thomas, Paul M.

AU - Kelleher, Neil L.

AU - Metcalf, William W.

AU - Van Der Donk, Wilfred A.

PY - 2007

Y1 - 2007

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AB - (Chemical Equation Presented) Third time's the charm! The structure of the phosphonate antibiotic A53868, first isolated in 1983 from Streptomyces luridus, has proven quite elusive. Originally reported as 1 and later revised to 2, the actual structure of the compound is the unusual dehydro aminophosphonic acid 3.

KW - Antibiotics

KW - Biosynthesis

KW - NMR spectroscopy

KW - Phosphonate

KW - Structure elucidation

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JF - Angewandte Chemie - International Edition

SN - 1433-7851

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ER -

Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid

Abstract

Keywords

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