Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid

John T. Whitteck*, Weijuan Ni, Benjamin M. Griffin, Andrew C. Eliot, Paul M. Thomas, Neil L. Kelleher, William W. Metcalf, Wilfred A. Van Der Donk

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

(Chemical Equation Presented) Third time's the charm! The structure of the phosphonate antibiotic A53868, first isolated in 1983 from Streptomyces luridus, has proven quite elusive. Originally reported as 1 and later revised to 2, the actual structure of the compound is the unusual dehydro aminophosphonic acid 3.

Original languageEnglish (US)
Pages (from-to)9089-9092
Number of pages4
JournalAngewandte Chemie - International Edition
Volume46
Issue number47
DOIs
StatePublished - 2007

Keywords

  • Antibiotics
  • Biosynthesis
  • NMR spectroscopy
  • Phosphonate
  • Structure elucidation

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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