Rebooting the collagen gel: Artificial hydrogels for the study of epithelial mesenchymal transformation

RW Dettman, HG Simon

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The collagen gel has been used to study epithelial–mesenchymal transformation (EMT) for over 30 years. With advances in the field of materials sciences, new options are available to design optically clear, three-dimensional nature-inspired matrix mimetics to study EMT. Here, we review the history of the collagen gel assay, discuss its current use and how newer artificial matrices can be built to simulate in vivo extracellular environments and investigate important current questions in the EMT field. We suggest that further collaborations between materials scientists and biologists will be critical to move the field of EMT forward. Developmental Dynamics 247:332–339, 2018.

Original languageEnglish (US)
Pages (from-to)332-339
Number of pages8
JournalDevelopmental Dynamics
Volume247
Issue number3
DOIs
StatePublished - Mar 2018

Keywords

  • EMT
  • artificial matrix
  • collagen gel
  • hydrogels

ASJC Scopus subject areas

  • Developmental Biology

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