Rebooting the collagen gel: Artificial hydrogels for the study of epithelial mesenchymal transformation

RW Dettman; HG Simon

doi:10.1002/dvdy.24560

Rebooting the collagen gel: Artificial hydrogels for the study of epithelial mesenchymal transformation

RW Dettman, HG Simon

Pediatrics

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The collagen gel has been used to study epithelial–mesenchymal transformation (EMT) for over 30 years. With advances in the field of materials sciences, new options are available to design optically clear, three-dimensional nature-inspired matrix mimetics to study EMT. Here, we review the history of the collagen gel assay, discuss its current use and how newer artificial matrices can be built to simulate in vivo extracellular environments and investigate important current questions in the EMT field. We suggest that further collaborations between materials scientists and biologists will be critical to move the field of EMT forward. Developmental Dynamics 247:332–339, 2018.

Original language	English (US)
Pages (from-to)	332-339
Number of pages	8
Journal	Developmental Dynamics
Volume	247
Issue number	3
DOIs	https://doi.org/10.1002/dvdy.24560
State	Published - Mar 2018

Keywords

EMT
artificial matrix
collagen gel
hydrogels

ASJC Scopus subject areas

Developmental Biology

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10.1002/dvdy.24560

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title = "Rebooting the collagen gel: Artificial hydrogels for the study of epithelial mesenchymal transformation",

abstract = "The collagen gel has been used to study epithelial–mesenchymal transformation (EMT) for over 30 years. With advances in the field of materials sciences, new options are available to design optically clear, three-dimensional nature-inspired matrix mimetics to study EMT. Here, we review the history of the collagen gel assay, discuss its current use and how newer artificial matrices can be built to simulate in vivo extracellular environments and investigate important current questions in the EMT field. We suggest that further collaborations between materials scientists and biologists will be critical to move the field of EMT forward. Developmental Dynamics 247:332–339, 2018.",

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AB - The collagen gel has been used to study epithelial–mesenchymal transformation (EMT) for over 30 years. With advances in the field of materials sciences, new options are available to design optically clear, three-dimensional nature-inspired matrix mimetics to study EMT. Here, we review the history of the collagen gel assay, discuss its current use and how newer artificial matrices can be built to simulate in vivo extracellular environments and investigate important current questions in the EMT field. We suggest that further collaborations between materials scientists and biologists will be critical to move the field of EMT forward. Developmental Dynamics 247:332–339, 2018.

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Rebooting the collagen gel: Artificial hydrogels for the study of epithelial mesenchymal transformation

Abstract

Keywords

ASJC Scopus subject areas

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