(Re)Building a Kidney

Leif Oxburgh, Thomas J. Carroll, Ondine Cleaver, Daniel R. Gossett, Deborah K. Hoshizaki, Jeffrey A. Hubbell, Benjamin D. Humphreys, Sanjay Jain, Jan Jensen, David L. Kaplan, Carl Kesselman, Christian J. Ketchum, Melissa H. Little, Andrew P. McMahon, Stuart J. Shankland, Jason R. Spence, M. Todd Valerius, Jason A. Wertheim, Oliver Wessely, Ying Zheng & 1 others Iain A. Drummond

Research output: Research - peer-reviewArticle

  • 1 Citations

Abstract

(Re)Building a Kidney is a National Institute of Diabetes and Digestive and Kidney Diseases-led consortium to optimize approaches for the isolation, expansion, and differentiation of appropriate kidney cell types and the integration of these cells into complex structures that replicate human kidney function. The ultimate goals of the consortium are two-fold: to develop and implement strategies for in vitro engineering of replacement kidney tissue, and to devise strategies to stimulate regeneration of nephrons in situ to restore failing kidney function. Projects within the consortium will answer fundamental questions regarding human gene expression in the developing kidney, essential signaling crosstalk between distinct cell types of the developing kidney, how to derive the many cell types of the kidney through directed differentiation of human pluripotent stem cells, which bioengineering or scaffolding strategies have the most potential for kidney tissue formation, and basic parameters of the regenerative response to injury. As these projects progress, the consortium will incorporate systematic investigations in physiologic function of in vitro and in vivo differentiated kidney tissue, strategies for engraftment in experimental animals, and development of therapeutic approaches to activate innate reparative responses.

LanguageEnglish
Pages1370-1378
Number of pages9
JournalJournal of the American Society of Nephrology : JASN
Volume28
Issue number5
DOIs
StatePublished - May 1 2017

Fingerprint

Kidney
In Vitro Techniques
National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
Bioengineering
Pluripotent Stem Cells
Nephrons
Regeneration
Gene Expression
Wounds and Injuries
Therapeutics

Keywords

  • Directed differentiation
  • Organogenesis
  • Organoid
  • Regeneration

ASJC Scopus subject areas

  • Nephrology

Cite this

Oxburgh, L., Carroll, T. J., Cleaver, O., Gossett, D. R., Hoshizaki, D. K., Hubbell, J. A., ... Drummond, I. A. (2017). (Re)Building a Kidney. Journal of the American Society of Nephrology : JASN, 28(5), 1370-1378. DOI: 10.1681/ASN.2016101077

(Re)Building a Kidney. / Oxburgh, Leif; Carroll, Thomas J.; Cleaver, Ondine; Gossett, Daniel R.; Hoshizaki, Deborah K.; Hubbell, Jeffrey A.; Humphreys, Benjamin D.; Jain, Sanjay; Jensen, Jan; Kaplan, David L.; Kesselman, Carl; Ketchum, Christian J.; Little, Melissa H.; McMahon, Andrew P.; Shankland, Stuart J.; Spence, Jason R.; Valerius, M. Todd; Wertheim, Jason A.; Wessely, Oliver; Zheng, Ying; Drummond, Iain A.

In: Journal of the American Society of Nephrology : JASN, Vol. 28, No. 5, 01.05.2017, p. 1370-1378.

Research output: Research - peer-reviewArticle

Oxburgh, L, Carroll, TJ, Cleaver, O, Gossett, DR, Hoshizaki, DK, Hubbell, JA, Humphreys, BD, Jain, S, Jensen, J, Kaplan, DL, Kesselman, C, Ketchum, CJ, Little, MH, McMahon, AP, Shankland, SJ, Spence, JR, Valerius, MT, Wertheim, JA, Wessely, O, Zheng, Y & Drummond, IA 2017, '(Re)Building a Kidney' Journal of the American Society of Nephrology : JASN, vol 28, no. 5, pp. 1370-1378. DOI: 10.1681/ASN.2016101077
Oxburgh L, Carroll TJ, Cleaver O, Gossett DR, Hoshizaki DK, Hubbell JA et al. (Re)Building a Kidney. Journal of the American Society of Nephrology : JASN. 2017 May 1;28(5):1370-1378. Available from, DOI: 10.1681/ASN.2016101077
Oxburgh, Leif ; Carroll, Thomas J. ; Cleaver, Ondine ; Gossett, Daniel R. ; Hoshizaki, Deborah K. ; Hubbell, Jeffrey A. ; Humphreys, Benjamin D. ; Jain, Sanjay ; Jensen, Jan ; Kaplan, David L. ; Kesselman, Carl ; Ketchum, Christian J. ; Little, Melissa H. ; McMahon, Andrew P. ; Shankland, Stuart J. ; Spence, Jason R. ; Valerius, M. Todd ; Wertheim, Jason A. ; Wessely, Oliver ; Zheng, Ying ; Drummond, Iain A./ (Re)Building a Kidney. In: Journal of the American Society of Nephrology : JASN. 2017 ; Vol. 28, No. 5. pp. 1370-1378
@article{62b88b8c3fdf4474b91fd5e68466d2dc,
title = "(Re)Building a Kidney",
abstract = "(Re)Building a Kidney is a National Institute of Diabetes and Digestive and Kidney Diseases-led consortium to optimize approaches for the isolation, expansion, and differentiation of appropriate kidney cell types and the integration of these cells into complex structures that replicate human kidney function. The ultimate goals of the consortium are two-fold: to develop and implement strategies for in vitro engineering of replacement kidney tissue, and to devise strategies to stimulate regeneration of nephrons in situ to restore failing kidney function. Projects within the consortium will answer fundamental questions regarding human gene expression in the developing kidney, essential signaling crosstalk between distinct cell types of the developing kidney, how to derive the many cell types of the kidney through directed differentiation of human pluripotent stem cells, which bioengineering or scaffolding strategies have the most potential for kidney tissue formation, and basic parameters of the regenerative response to injury. As these projects progress, the consortium will incorporate systematic investigations in physiologic function of in vitro and in vivo differentiated kidney tissue, strategies for engraftment in experimental animals, and development of therapeutic approaches to activate innate reparative responses.",
keywords = "Directed differentiation, Organogenesis, Organoid, Regeneration",
author = "Leif Oxburgh and Carroll, {Thomas J.} and Ondine Cleaver and Gossett, {Daniel R.} and Hoshizaki, {Deborah K.} and Hubbell, {Jeffrey A.} and Humphreys, {Benjamin D.} and Sanjay Jain and Jan Jensen and Kaplan, {David L.} and Carl Kesselman and Ketchum, {Christian J.} and Little, {Melissa H.} and McMahon, {Andrew P.} and Shankland, {Stuart J.} and Spence, {Jason R.} and Valerius, {M. Todd} and Wertheim, {Jason A.} and Oliver Wessely and Ying Zheng and Drummond, {Iain A.}",
year = "2017",
month = "5",
doi = "10.1681/ASN.2016101077",
volume = "28",
pages = "1370--1378",
journal = "Journal of the American Society of Nephrology : JASN",
issn = "1046-6673",
publisher = "American Society of Nephrology",
number = "5",

}

TY - JOUR

T1 - (Re)Building a Kidney

AU - Oxburgh,Leif

AU - Carroll,Thomas J.

AU - Cleaver,Ondine

AU - Gossett,Daniel R.

AU - Hoshizaki,Deborah K.

AU - Hubbell,Jeffrey A.

AU - Humphreys,Benjamin D.

AU - Jain,Sanjay

AU - Jensen,Jan

AU - Kaplan,David L.

AU - Kesselman,Carl

AU - Ketchum,Christian J.

AU - Little,Melissa H.

AU - McMahon,Andrew P.

AU - Shankland,Stuart J.

AU - Spence,Jason R.

AU - Valerius,M. Todd

AU - Wertheim,Jason A.

AU - Wessely,Oliver

AU - Zheng,Ying

AU - Drummond,Iain A.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - (Re)Building a Kidney is a National Institute of Diabetes and Digestive and Kidney Diseases-led consortium to optimize approaches for the isolation, expansion, and differentiation of appropriate kidney cell types and the integration of these cells into complex structures that replicate human kidney function. The ultimate goals of the consortium are two-fold: to develop and implement strategies for in vitro engineering of replacement kidney tissue, and to devise strategies to stimulate regeneration of nephrons in situ to restore failing kidney function. Projects within the consortium will answer fundamental questions regarding human gene expression in the developing kidney, essential signaling crosstalk between distinct cell types of the developing kidney, how to derive the many cell types of the kidney through directed differentiation of human pluripotent stem cells, which bioengineering or scaffolding strategies have the most potential for kidney tissue formation, and basic parameters of the regenerative response to injury. As these projects progress, the consortium will incorporate systematic investigations in physiologic function of in vitro and in vivo differentiated kidney tissue, strategies for engraftment in experimental animals, and development of therapeutic approaches to activate innate reparative responses.

AB - (Re)Building a Kidney is a National Institute of Diabetes and Digestive and Kidney Diseases-led consortium to optimize approaches for the isolation, expansion, and differentiation of appropriate kidney cell types and the integration of these cells into complex structures that replicate human kidney function. The ultimate goals of the consortium are two-fold: to develop and implement strategies for in vitro engineering of replacement kidney tissue, and to devise strategies to stimulate regeneration of nephrons in situ to restore failing kidney function. Projects within the consortium will answer fundamental questions regarding human gene expression in the developing kidney, essential signaling crosstalk between distinct cell types of the developing kidney, how to derive the many cell types of the kidney through directed differentiation of human pluripotent stem cells, which bioengineering or scaffolding strategies have the most potential for kidney tissue formation, and basic parameters of the regenerative response to injury. As these projects progress, the consortium will incorporate systematic investigations in physiologic function of in vitro and in vivo differentiated kidney tissue, strategies for engraftment in experimental animals, and development of therapeutic approaches to activate innate reparative responses.

KW - Directed differentiation

KW - Organogenesis

KW - Organoid

KW - Regeneration

UR - http://www.scopus.com/inward/record.url?scp=85021850376&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021850376&partnerID=8YFLogxK

U2 - 10.1681/ASN.2016101077

DO - 10.1681/ASN.2016101077

M3 - Article

VL - 28

SP - 1370

EP - 1378

JO - Journal of the American Society of Nephrology : JASN

T2 - Journal of the American Society of Nephrology : JASN

JF - Journal of the American Society of Nephrology : JASN

SN - 1046-6673

IS - 5

ER -