Recent advancements of flow cytometry: New applications in hematology and oncology

Janghee Woo*, Alexandra Baumann, Vivian Arguello

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

Flow cytometry offers great diagnostic opportunities in the vast majority of hematologic and oncologic diseases with multiple cellular and molecular information within an individual cell. We will discuss various applications of flow cytometry, particularly in hematology and oncology, in addition to general principles and limitations of flow cytometry. They include nucleic acid analyses in cancer cells, new methods for assessing rare circulating tumor cells and disease-specific applications in malignancy with emphasis on diagnosis and treatment of hematologic malignancy, including minimal residual disease. With improvement of monoclonal antibodies, fluorescence and laser technology, flow cytometry now offers new avenues of assessing cellular functionality through examination of intracellular compartments. High-throughput quantitative analysis, advancements of in vivo flow cytometry and assessment of minimal residual diseases, as exampled in patient stratification and prediction of leukemia therapeutic response, will further make flow cytometry indispensable in medicine.

Original languageEnglish (US)
Pages (from-to)67-81
Number of pages15
JournalExpert Review of Molecular Diagnostics
Volume14
Issue number1
DOIs
StatePublished - Jan 2014
Externally publishedYes

Keywords

  • Applications
  • Flow cytometry
  • In vivo flow cytometry and standardization of flow cytometry
  • Minimal residual disease
  • Qualitative and functional assays

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Molecular Biology
  • Genetics

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