Recent Advances in Materials, Devices, and Systems for Neural Interfaces

Sang Min Won, Enming Song, Jianing Zhao, Jinghua Li, Jonathan Rivnay, John A. Rogers*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

135 Scopus citations


Technologies capable of establishing intimate, long-lived optical/electrical interfaces to neural systems will play critical roles in neuroscience research and in the development of nonpharmacological treatments for neurological disorders. The development of high-density interfaces to 3D populations of neurons across entire tissue systems in living animals, including human subjects, represents a grand challenge for the field, where advanced biocompatible materials and engineered structures for electrodes and light emitters will be essential. This review summarizes recent progress in these directions, with an emphasis on the most promising demonstrated concepts, materials, devices, and systems. The article begins with an overview of electrode materials with enhanced electrical and/or mechanical performance, in forms ranging from planar films, to micro/nanostructured surfaces, to 3D porous frameworks and soft composites. Subsequent sections highlight integration with active materials and components for multiplexed addressing, local amplification, wireless data transmission, and power harvesting, with multimodal operation in soft, shape-conformal systems. These advances establish the foundations for scalable architectures in optical/electrical neural interfaces of the future, where a blurring of the lines between biotic and abiotic systems will catalyze profound progress in neuroscience research and in human health/well-being.

Original languageEnglish (US)
Article number1800534
JournalAdvanced Materials
Issue number30
StatePublished - Jul 26 2018


  • bioelectronics
  • electrodes
  • neural interfaces
  • neural recording
  • neural stimulation

ASJC Scopus subject areas

  • General Materials Science
  • Mechanics of Materials
  • Mechanical Engineering


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