Recent advances in Parkinson's disease genetics

Steven Lubbe, Huw R. Morris*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations

Abstract

The last 5 years have seen rapid progress in Parkinson's disease (PD) genetics, with the publication of a series of large-scale genome wide association studies for PD, and evaluation of the roles of the LRRK2 and GBA genes in the aetiology of PD. We are beginning to develop a coherent picture of the interplay of Mendelian and non-Mendelian factors in PD. Pathways involved in mitochondrial quality control (mitophagy), lysosomal function and immune function are emerging as important in the pathogenesis of PD. These pathways represent a target for therapeutic intervention and a way in which the heterogeneity of disease cause, as well as disease mechanism, can be established. In the future, there is likely to be an individualised basis for the treatment of PD, linked to the identification of specific genetic factors.

Original languageEnglish (US)
Pages (from-to)259-266
Number of pages8
JournalJournal of Neurology
Volume261
Issue number2
DOIs
StatePublished - Feb 2014

Keywords

  • GBA
  • Genetics
  • Genome wide-association study
  • LRRK2
  • Parkin
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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