Recent advances in targetable therapeutics in metastatic non-squamous NSCLC

Pranshu Bansal, Diaa Osman, Gregory N. Gan, George R. Simon, Yanis Boumber*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

27 Scopus citations


Lung adenocarcinoma is the most common subtype of non-small cell lung cancer (NSCLC). With the discovery of epidermal growth factor receptor (EGFR) mutations, anaplastic lymphoma kinase (ALK) rearrangements, and effective targeted therapies, therapeutic options are expanding for patients with lung adenocarcinoma. Here, we review novel therapies in non-squamous NSCLC, which are directed against oncogenic targets, including EGFR, ALK, ROS1, BRAF, MET, human epidermal growth factor receptor 2 (HER2), vascular endothelial growth factor receptor 2 (VEGFR2), RET, and NTRK. With the rapidly evolving molecular testing and development of new targeted agents, our ability to further personalize therapy in non-squamous NSCLC is rapidly expanding.

Original languageEnglish (US)
Article number112
JournalFrontiers in Oncology
Issue numberMAY
StatePublished - 2016
Externally publishedYes


  • ALK
  • BRAF
  • C-MET
  • EGFR
  • HER2
  • ROS1
  • VEGFR2

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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