TY - JOUR
T1 - Recent advances in the pharmacotherapy of schxzophrenia
AU - Meltzer, Herbert Y.
AU - Lee, Myung A.
AU - Ranjan, Rakesh
PY - 1994/11
Y1 - 1994/11
N2 - The major advance in the psychopharmacology of schizophrenia has been the rediscovery of clozapine and the development of other novel antipsychotic drugs, all of which are superior to typical neuroleptic drugs with regard to extrapyramidal symptoms. Clozapine, the best studied of these agents, is also superior in efficacy with regard to psychopathology and cognitive function and has been shown not to cause tardive dyskinesia. A variety of other novel agents, e.g., risperidone, olanazpine, amperozide, seroquel, sertindole, zaprisidone and melperone, must be further studied to establish their efficacy relative to clozapine or the typical neuroleptics, or both. It is likely that these novel agents will displace the typical neuroleptic drugs as the primary treatment of schizophrenia.
AB - The major advance in the psychopharmacology of schizophrenia has been the rediscovery of clozapine and the development of other novel antipsychotic drugs, all of which are superior to typical neuroleptic drugs with regard to extrapyramidal symptoms. Clozapine, the best studied of these agents, is also superior in efficacy with regard to psychopathology and cognitive function and has been shown not to cause tardive dyskinesia. A variety of other novel agents, e.g., risperidone, olanazpine, amperozide, seroquel, sertindole, zaprisidone and melperone, must be further studied to establish their efficacy relative to clozapine or the typical neuroleptics, or both. It is likely that these novel agents will displace the typical neuroleptic drugs as the primary treatment of schizophrenia.
KW - clozapine
KW - neuroleptic drug
KW - risperidone
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U2 - 10.1111/j.1600-0447.1994.tb05897.x
DO - 10.1111/j.1600-0447.1994.tb05897.x
M3 - Article
C2 - 7533472
AN - SCOPUS:0028062934
SN - 0001-690X
VL - 90
SP - 95
EP - 101
JO - Acta Psychiatrica Scandinavica
JF - Acta Psychiatrica Scandinavica
ER -