Recent advances on the roles of epidermal growth factor receptor in psoriasis

Sijia Wang, Zhuoli Zhang, Han Peng, Kang Zeng*

*Corresponding author for this work

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Epidermal growth factor receptor (EGFR) is a well-characterized receptor tyrosine kinase that involved in many vital activities in cell development, such as cellular homeostasis, proliferation, division, differentiation and apoptosis. Natural activation of EGFR and the concomitant downstream signaling pathways regulation are substantial to maintain normal cellular functions. In recent studies, EGFR was demonstrated to be a fundamental modulator in the control of skin inflammatory responses. Several dermatologic diseases including psoriasis are related to the anomalous activation of EGFR signaling. It has been proved that the expression and activity of EGFR and its endogenous ligands are overexpressed in the active epidermis lesions of psoriasis. Moreover, the remarkable therapeutic improvement of chronic psoriasis in cancer patients during the treatment of EGFR inhibitors or anti-EGFR monoclonal antibodies are also recorded, suggesting that the EGFR-mediated signaling may conduct a crucial role in the pathophysiology of psoriasis.

Original languageEnglish (US)
Article numberAJTR0071057
Pages (from-to)520-528
Number of pages9
JournalAmerican Journal of Translational Research
Volume11
Issue number2
StatePublished - Jan 1 2019

Keywords

  • EGF
  • EGFR
  • Keratinocytes
  • Psoriasis

ASJC Scopus subject areas

  • Molecular Medicine
  • Clinical Biochemistry
  • Cancer Research

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