Recent developments in myofibroblast biology: Paradigms for connective tissue remodeling

Boris Hinz*, Sem H. Phan, Victor J. Thannickal, Marco Prunotto, Alexis Desmoulire, John Varga, Olivier De Wever, Marc Mareel, Giulio Gabbiani

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

761 Scopus citations

Abstract

The discovery of the myofibroblast has opened new perspectives for the comprehension of the biological mechanisms involved in wound healing and fibrotic diseases. In recent years, many advances have been made in understanding important aspects of myofibroblast basic biological characteristics. This review summarizes such advances in several fields, such as the following: i) force production by the myofibroblast and mechanisms of connective tissue remodeling; ii) factors controlling the expression of α-smooth muscle actin, the most used marker of myofibroblastic phenotype and, more important, involved in force generation by the myofibroblast; and iii) factors affecting genesis of the myofibroblast and its differentiation from precursor cells, in particular epigenetic factors, such as DNA methylation, microRNAs, and histone modification. We also review the origin and the specific features of the myofibroblast in diverse fibrotic lesions, such as systemic sclerosis; kidney, liver, and lung fibrosis; and the stromal reaction to certain epithelial tumors. Finally, we summarize the emerging strategies for influencing myofibroblast behavior in vitro and in vivo, with the ultimate goal of an effective therapeutic approach for myofibroblast-dependent diseases.

Original languageEnglish (US)
Pages (from-to)1340-1355
Number of pages16
JournalAmerican Journal of Pathology
Volume180
Issue number4
DOIs
StatePublished - Apr 2012

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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