Recent genetic discoveries implicating ion channels in human cardiovascular diseases

Alfred L. George*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

The term 'channelopathy' refers to human genetic disorders caused by mutations in genes encoding ion channels or their interacting proteins. Recent advances in this field have been enabled by next-generation DNA sequencing strategies such as whole exome sequencing with several intriguing and unexpected discoveries. This review highlights important discoveries implicating ion channels or ion channel modulators in cardiovascular disorders including cardiac arrhythmia susceptibility, cardiac conduction phenotypes, pulmonary and systemic hypertension. These recent discoveries further emphasize the importance of ion channels in the pathophysiology of human disease and as important druggable targets.

Original languageEnglish (US)
Pages (from-to)47-52
Number of pages6
JournalCurrent Opinion in Pharmacology
Volume15
Issue number1
DOIs
StatePublished - Apr 2014

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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