Recent Progress in Lyme Disease and Remaining Challenges

Jason R. Bobe; Brandon L. Jutras; Elizabeth J. Horn; Monica E. Embers; Allison Bailey; Robert L. Moritz; Ying Zhang; Mark J. Soloski; Richard S. Ostfeld; Richard T. Marconi; John Aucott; Avi Ma'ayan; Felicia Keesing; Kim Lewis; Choukri Ben Mamoun; Alison W. Rebman; Mecaila E. McClune; Edward B. Breitschwerdt; Panga Jaipal Reddy; Ricardo Maggi; Frank Yang; Bennett Nemser; Aydogan Ozcan; Omai Garner; Dino Di Carlo; Zachary Ballard; Hyou Arm Joung; Albert Garcia-Romeu; Roland R. Griffiths; Nicole Baumgarth; Brian A. Fallon

doi:10.3389/fmed.2021.666554

Recent Progress in Lyme Disease and Remaining Challenges

Jason R. Bobe^*, Brandon L. Jutras, Elizabeth J. Horn, Monica E. Embers, Allison Bailey, Robert L. Moritz, Ying Zhang, Mark J. Soloski, Richard S. Ostfeld, Richard T. Marconi, John Aucott, Avi Ma'ayan, Felicia Keesing, Kim Lewis, Choukri Ben Mamoun, Alison W. Rebman, Mecaila E. McClune, Edward B. Breitschwerdt, Panga Jaipal Reddy, Ricardo MaggiFrank Yang, Bennett Nemser, Aydogan Ozcan, Omai Garner, Dino Di Carlo, Zachary Ballard, Hyou Arm Joung, Albert Garcia-Romeu, Roland R. Griffiths, Nicole Baumgarth, Brian A. Fallon

^*Corresponding author for this work

Microbiology-Immunology

Research output: Contribution to journal › Review article › peer-review

67 Scopus citations

Abstract

Lyme disease (also known as Lyme borreliosis) is the most common vector-borne disease in the United States with an estimated 476,000 cases per year. While historically, the long-term impact of Lyme disease on patients has been controversial, mounting evidence supports the idea that a substantial number of patients experience persistent symptoms following treatment. The research community has largely lacked the necessary funding to properly advance the scientific and clinical understanding of the disease, or to develop and evaluate innovative approaches for prevention, diagnosis, and treatment. Given the many outstanding questions raised into the diagnosis, clinical presentation and treatment of Lyme disease, and the underlying molecular mechanisms that trigger persistent disease, there is an urgent need for more support. This review article summarizes progress over the past 5 years in our understanding of Lyme and tick-borne diseases in the United States and highlights remaining challenges.

Original language	English (US)
Article number	666554
Journal	Frontiers in Medicine
Volume	8
DOIs	https://doi.org/10.3389/fmed.2021.666554
State	Published - Aug 18 2021

Funding

All authors are supported by funding from the Steven & Alexandra Cohen Foundation. Additional funding is provided by grants from the Global Lyme Alliance and NIH/NIAID R01AI157007 (NB); Bay Area Lyme Foundation (JRB); NIH R01 AI083640 (FY); NIAID/NIH R21AI133335 and R21AI142302 (RLM and PJR).

Keywords

diagnosis
field building
Lyme disease
pathogenesis
prevention
PTLD
treatment
vaccine

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3389/fmed.2021.666554

Cite this

Bobe, J. R., Jutras, B. L., Horn, E. J., Embers, M. E., Bailey, A., Moritz, R. L., Zhang, Y., Soloski, M. J., Ostfeld, R. S., Marconi, R. T., Aucott, J., Ma'ayan, A., Keesing, F., Lewis, K., Ben Mamoun, C., Rebman, A. W., McClune, M. E., Breitschwerdt, E. B., Reddy, P. J., ... Fallon, B. A. (2021). Recent Progress in Lyme Disease and Remaining Challenges. Frontiers in Medicine, 8, Article 666554. https://doi.org/10.3389/fmed.2021.666554

@article{66afbf32be2f4900aaa4c583fe3381bb,

title = "Recent Progress in Lyme Disease and Remaining Challenges",

abstract = "Lyme disease (also known as Lyme borreliosis) is the most common vector-borne disease in the United States with an estimated 476,000 cases per year. While historically, the long-term impact of Lyme disease on patients has been controversial, mounting evidence supports the idea that a substantial number of patients experience persistent symptoms following treatment. The research community has largely lacked the necessary funding to properly advance the scientific and clinical understanding of the disease, or to develop and evaluate innovative approaches for prevention, diagnosis, and treatment. Given the many outstanding questions raised into the diagnosis, clinical presentation and treatment of Lyme disease, and the underlying molecular mechanisms that trigger persistent disease, there is an urgent need for more support. This review article summarizes progress over the past 5 years in our understanding of Lyme and tick-borne diseases in the United States and highlights remaining challenges.",

keywords = "diagnosis, field building, Lyme disease, pathogenesis, prevention, PTLD, treatment, vaccine",

author = "Bobe, {Jason R.} and Jutras, {Brandon L.} and Horn, {Elizabeth J.} and Embers, {Monica E.} and Allison Bailey and Moritz, {Robert L.} and Ying Zhang and Soloski, {Mark J.} and Ostfeld, {Richard S.} and Marconi, {Richard T.} and John Aucott and Avi Ma'ayan and Felicia Keesing and Kim Lewis and {Ben Mamoun}, Choukri and Rebman, {Alison W.} and McClune, {Mecaila E.} and Breitschwerdt, {Edward B.} and Reddy, {Panga Jaipal} and Ricardo Maggi and Frank Yang and Bennett Nemser and Aydogan Ozcan and Omai Garner and {Di Carlo}, Dino and Zachary Ballard and Joung, {Hyou Arm} and Albert Garcia-Romeu and Griffiths, {Roland R.} and Nicole Baumgarth and Fallon, {Brian A.}",

note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Bobe, Jutras, Horn, Embers, Bailey, Moritz, Zhang, Soloski, Ostfeld, Marconi, Aucott, Ma'ayan, Keesing, Lewis, Ben Mamoun, Rebman, McClune, Breitschwerdt, Reddy, Maggi, Yang, Nemser, Ozcan, Garner, Di Carlo, Ballard, Joung, Garcia-Romeu, Griffiths, Baumgarth and Fallon.",

year = "2021",

month = aug,

day = "18",

doi = "10.3389/fmed.2021.666554",

language = "English (US)",

volume = "8",

journal = "Frontiers in Medicine",

issn = "2296-858X",

publisher = "Frontiers Media S. A.",

}

Bobe, JR, Jutras, BL, Horn, EJ, Embers, ME, Bailey, A, Moritz, RL, Zhang, Y, Soloski, MJ, Ostfeld, RS, Marconi, RT, Aucott, J, Ma'ayan, A, Keesing, F, Lewis, K, Ben Mamoun, C, Rebman, AW, McClune, ME, Breitschwerdt, EB, Reddy, PJ, Maggi, R, Yang, F, Nemser, B, Ozcan, A, Garner, O, Di Carlo, D, Ballard, Z, Joung, HA, Garcia-Romeu, A, Griffiths, RR, Baumgarth, N & Fallon, BA 2021, 'Recent Progress in Lyme Disease and Remaining Challenges', Frontiers in Medicine, vol. 8, 666554. https://doi.org/10.3389/fmed.2021.666554

TY - JOUR

T1 - Recent Progress in Lyme Disease and Remaining Challenges

AU - Bobe, Jason R.

AU - Jutras, Brandon L.

AU - Horn, Elizabeth J.

AU - Embers, Monica E.

AU - Bailey, Allison

AU - Moritz, Robert L.

AU - Zhang, Ying

AU - Soloski, Mark J.

AU - Ostfeld, Richard S.

AU - Marconi, Richard T.

AU - Aucott, John

AU - Ma'ayan, Avi

AU - Keesing, Felicia

AU - Lewis, Kim

AU - Ben Mamoun, Choukri

AU - Rebman, Alison W.

AU - McClune, Mecaila E.

AU - Breitschwerdt, Edward B.

AU - Reddy, Panga Jaipal

AU - Maggi, Ricardo

AU - Yang, Frank

AU - Nemser, Bennett

AU - Ozcan, Aydogan

AU - Garner, Omai

AU - Di Carlo, Dino

AU - Ballard, Zachary

AU - Joung, Hyou Arm

AU - Garcia-Romeu, Albert

AU - Griffiths, Roland R.

AU - Baumgarth, Nicole

AU - Fallon, Brian A.

N1 - Publisher Copyright: © Copyright © 2021 Bobe, Jutras, Horn, Embers, Bailey, Moritz, Zhang, Soloski, Ostfeld, Marconi, Aucott, Ma'ayan, Keesing, Lewis, Ben Mamoun, Rebman, McClune, Breitschwerdt, Reddy, Maggi, Yang, Nemser, Ozcan, Garner, Di Carlo, Ballard, Joung, Garcia-Romeu, Griffiths, Baumgarth and Fallon.

PY - 2021/8/18

Y1 - 2021/8/18

N2 - Lyme disease (also known as Lyme borreliosis) is the most common vector-borne disease in the United States with an estimated 476,000 cases per year. While historically, the long-term impact of Lyme disease on patients has been controversial, mounting evidence supports the idea that a substantial number of patients experience persistent symptoms following treatment. The research community has largely lacked the necessary funding to properly advance the scientific and clinical understanding of the disease, or to develop and evaluate innovative approaches for prevention, diagnosis, and treatment. Given the many outstanding questions raised into the diagnosis, clinical presentation and treatment of Lyme disease, and the underlying molecular mechanisms that trigger persistent disease, there is an urgent need for more support. This review article summarizes progress over the past 5 years in our understanding of Lyme and tick-borne diseases in the United States and highlights remaining challenges.

AB - Lyme disease (also known as Lyme borreliosis) is the most common vector-borne disease in the United States with an estimated 476,000 cases per year. While historically, the long-term impact of Lyme disease on patients has been controversial, mounting evidence supports the idea that a substantial number of patients experience persistent symptoms following treatment. The research community has largely lacked the necessary funding to properly advance the scientific and clinical understanding of the disease, or to develop and evaluate innovative approaches for prevention, diagnosis, and treatment. Given the many outstanding questions raised into the diagnosis, clinical presentation and treatment of Lyme disease, and the underlying molecular mechanisms that trigger persistent disease, there is an urgent need for more support. This review article summarizes progress over the past 5 years in our understanding of Lyme and tick-borne diseases in the United States and highlights remaining challenges.

KW - diagnosis

KW - field building

KW - Lyme disease

KW - pathogenesis

KW - prevention

KW - PTLD

KW - treatment

KW - vaccine

UR - http://www.scopus.com/inward/record.url?scp=85114387999&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85114387999&partnerID=8YFLogxK

U2 - 10.3389/fmed.2021.666554

DO - 10.3389/fmed.2021.666554

M3 - Review article

C2 - 34485323

AN - SCOPUS:85114387999

SN - 2296-858X

VL - 8

JO - Frontiers in Medicine

JF - Frontiers in Medicine

M1 - 666554

ER -

Recent Progress in Lyme Disease and Remaining Challenges

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this