Recent strategies and tactics for the enantioselective total syntheses of cyclolignan natural products

Rebekah G. Reynolds, Huong Quynh Anh Nguyen, Jordan C.T. Reddel, Regan J. Thomson*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Covering: 2000 to 2021 Lignan natural products are found in many different plant species and possess numerous useful biological properties, such as anti-inflammatory, antiviral, antioxidant, antibacterial, and antitumor activities. Their utility in both traditional and conventional medicine, coupled with their structural diversity has made them popular synthetic targets over many decades. This review specifically addresses the cyclolignan subclass of the family, which possess both a C8-C8′ and a C2-C7′ linkage between two different phenylpropene units. We present a comprehensive overview of the diverse strategies employed by chemists to achieve enantioselective total syntheses of cyclolignans covering: 2000 to 2021.

Original languageEnglish (US)
Pages (from-to)670-702
Number of pages33
JournalNatural product reports
Volume39
Issue number3
DOIs
StatePublished - Oct 19 2021

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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