TY - JOUR
T1 - Recent strategies and tactics for the enantioselective total syntheses of cyclolignan natural products
AU - Reynolds, Rebekah G.
AU - Nguyen, Huong Quynh Anh
AU - Reddel, Jordan C.T.
AU - Thomson, Regan J.
N1 - Funding Information:
We thank the National Science Foundation (CHE0845063) and The National Institutes of Health (NIHGMS 1R01GM124089) for generous financial support. RGR would like to acknowledge the ARCS® (Achievement Rewards for College Scientists) Foundation, Inc.‘s Scholar Illinois Chapter [7/1/20-6/30/21].
Publisher Copyright:
© 2022 The Royal Society of Chemistry
PY - 2021/10/19
Y1 - 2021/10/19
N2 - Covering: 2000 to 2021 Lignan natural products are found in many different plant species and possess numerous useful biological properties, such as anti-inflammatory, antiviral, antioxidant, antibacterial, and antitumor activities. Their utility in both traditional and conventional medicine, coupled with their structural diversity has made them popular synthetic targets over many decades. This review specifically addresses the cyclolignan subclass of the family, which possess both a C8-C8′ and a C2-C7′ linkage between two different phenylpropene units. We present a comprehensive overview of the diverse strategies employed by chemists to achieve enantioselective total syntheses of cyclolignans covering: 2000 to 2021.
AB - Covering: 2000 to 2021 Lignan natural products are found in many different plant species and possess numerous useful biological properties, such as anti-inflammatory, antiviral, antioxidant, antibacterial, and antitumor activities. Their utility in both traditional and conventional medicine, coupled with their structural diversity has made them popular synthetic targets over many decades. This review specifically addresses the cyclolignan subclass of the family, which possess both a C8-C8′ and a C2-C7′ linkage between two different phenylpropene units. We present a comprehensive overview of the diverse strategies employed by chemists to achieve enantioselective total syntheses of cyclolignans covering: 2000 to 2021.
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U2 - 10.1039/d1np00057h
DO - 10.1039/d1np00057h
M3 - Review article
C2 - 34664594
AN - SCOPUS:85124605494
SN - 0265-0568
VL - 39
SP - 670
EP - 702
JO - Natural product reports
JF - Natural product reports
IS - 3
ER -