Recent Technical Developments in ASL: A Review of the State of the Art

Luis Hernandez-Garcia*, Verónica Aramendía-Vidaurreta, Divya S. Bolar, Weiying Dai, Maria A. Fernández-Seara, Jia Guo, Ananth J. Madhuranthakam, Henk Mutsaerts, Jan Petr, Qin Qin, Jonas Schollenberger, Yuriko Suzuki, Manuel Taso, David L. Thomas, Matthias J.P. van Osch, Joseph Woods, Moss Y. Zhao, Lirong Yan, Ze Wang, Li ZhaoThomas W. Okell

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations

Abstract

This review article provides an overview of a range of recent technical developments in advanced arterial spin labeling (ASL) methods that have been developed or adopted by the community since the publication of a previous ASL consensus paper by Alsop et al. It is part of a series of review/recommendation papers from the International Society for Magnetic Resonance in Medicine Perfusion Study Group. Here, we focus on advancements in readouts and trajectories, image reconstruction, noise reduction, partial volume correction, quantification of nonperfusion parameters, fMRI, fingerprinting, vessel selective ASL, angiography, deep learning, and ultrahigh field ASL. We aim to provide a high level of understanding of these new approaches and some guidance for their implementation, with the goal of facilitating the adoption of such advances by research groups and by MRI vendors. Topics outside the scope of this article that are reviewed at length in separate articles include velocity selective ASL, multiple-timepoint ASL, body ASL, and clinical ASL recommendations.

Original languageEnglish (US)
Pages (from-to)2021-2042
Number of pages22
JournalMagnetic resonance in medicine
Volume88
Issue number5
DOIs
StatePublished - Nov 2022

Funding

This research was funded in whole or in part by: the Wellcome Trust (grant numbers 220204/Z/20/Z and 203139/Z/16/Z, and Centre award 539208). For the purpose of open access, the author has applied a CC BY public copyright license to any Author Accepted Manuscript version arising from this submission. h.m . and j.p are supported by the Dutch Heart Foundation (2020T049); by the Eurostars‐2 joint programme with cofunding from the European Union Horizon 2020 research and innovation programme (ASPIRE E!113701), provided by the Netherlands Enterprise Agency (RvO); and by the EU Joint Program for Neurodegenerative Disease Research, provided by the Netherlands Organization for Health Research and Development and Alzheimer Nederland (DEBBIE JPND2020‐568‐106). m.y.z . is supported by the American Heart Association (grant number 826254) and National Institutes of Health (grant number: R01EB025220‐02). d.l.t. is supported by the UCL Leonard Wolfson Experimental Neurology Centre (PR/ylr/18575) and the UCLH NIHR Biomedical Research Centre. l.h.g. is supported by the NIH (grant numbers NS108042, NS112233). m.j.p .v o . is supported by the research programme Innovational Research Incentives Scheme Vici (project number 016.160.351), which is financed by the Netherlands Organization for Scientific Research (NWO). American Heart Association, Grant/Award Number: 826254; EU Joint Program for Neurodegenerative Disease Research, Grant/Award Number: ASPIRE E!113701; Hartstichting, Grant/Award Number: 2020T049; National Institutes of Health, Grant/Award Numbers: NS108042; NS112233; R01EB025220‐02; Netherlands Organisation for Scientific Research (NWO), Grant/Award Number: 016.160.351; Research and Development and Alzheimer Nederland, Grant/Award Number: JPND2020‐568‐106; Rijksdienst voor Ondernemend Nederland, Grant/Award Number: ASPIRE E!113701; UCL Leonard Wolfson Experimental Neurology Centre, Grant/Award Number: PR/ylr/18575; UCLH NIHR Biomedical Research Centre, Wellcome Trust, Grant/Award Numbers: 203139/Z/16/Z; 220204/Z/20/Z; 539208 Funding information

Keywords

  • CBF
  • MR imaging
  • arterial spin labeling
  • perfusion
  • technical advances
  • vascular imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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