TY - JOUR
T1 - Reciprocal interactions between endothelial cells and macrophages in angiogenic vascular niches
AU - Baer, Caroline
AU - Squadrito, Mario Leonardo
AU - Iruela-Arispe, M. Luisa
AU - De Palma, Michele
N1 - Funding Information:
Work in the authors' laboratories was supported by grants from the European Research Council (TIE2+MONOCYTES), the Swiss National Centers of Competence in Research (NCCR), the Swiss National Science Foundation (SNSF), Anna Fuller Fund (to MDP) ; and the California Institute for Regenerative Medicine Award ( RB1-01328 , to MLIA).
PY - 2013/7/1
Y1 - 2013/7/1
N2 - The ability of macrophages to promote vascular growth has been associated with the secretion and local delivery of classic proangiogenic factors (e.g., VEGF-A and proteases). More recently, a series of studies have also revealed that physical contact of macrophages with growing blood vessels coordinates vascular fusion of emerging sprouts. Interestingly, the interactions between macrophages and vascular endothelial cells (ECs) appear to be bidirectional, such that activated ECs also support the expansion and differentiation of proangiogenic macrophages from myeloid progenitors. Here, we discuss recent findings suggesting that dynamic angiogenic vascular niches might also exist in vivo, e.g. in tumors, where sprouting blood vessels and immature myeloid cells like monocytes engage in heterotypic interactions that are required for angiogenesis. Finally, we provide an account of emerging mechanisms of cell-to-cell communication that rely on secreted microvesicles, such as exosomes, which can offer a vehicle for the rapid exchange of molecules and genetic information between macrophages and ECs engaged in angiogenesis.
AB - The ability of macrophages to promote vascular growth has been associated with the secretion and local delivery of classic proangiogenic factors (e.g., VEGF-A and proteases). More recently, a series of studies have also revealed that physical contact of macrophages with growing blood vessels coordinates vascular fusion of emerging sprouts. Interestingly, the interactions between macrophages and vascular endothelial cells (ECs) appear to be bidirectional, such that activated ECs also support the expansion and differentiation of proangiogenic macrophages from myeloid progenitors. Here, we discuss recent findings suggesting that dynamic angiogenic vascular niches might also exist in vivo, e.g. in tumors, where sprouting blood vessels and immature myeloid cells like monocytes engage in heterotypic interactions that are required for angiogenesis. Finally, we provide an account of emerging mechanisms of cell-to-cell communication that rely on secreted microvesicles, such as exosomes, which can offer a vehicle for the rapid exchange of molecules and genetic information between macrophages and ECs engaged in angiogenesis.
KW - Angiogenesis
KW - Blood vessel
KW - Exosome
KW - Heterotypic cell interaction
KW - Macrophage
KW - Microvesicle
KW - Monocyte
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U2 - 10.1016/j.yexcr.2013.03.026
DO - 10.1016/j.yexcr.2013.03.026
M3 - Review article
C2 - 23542777
AN - SCOPUS:84879601600
SN - 0014-4827
VL - 319
SP - 1626
EP - 1634
JO - Experimental Cell Research
JF - Experimental Cell Research
IS - 11
ER -