Abstract
The rational design of a recognition-based system that is capable of accelerating and controlling the regiochemical outcome of a dipolar cycloaddition reaction between an azide and an alkyne is presented. The origins of the acceleration and control of the cycloaddition reactions are rationalized - using molecular mechanics calculations - in terms of the formation of a complex between the reagents which organizes and orients them prior to reaction.
Original language | English (US) |
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Pages (from-to) | 4945-4954 |
Number of pages | 10 |
Journal | Tetrahedron |
Volume | 57 |
Issue number | 23 |
DOIs | |
State | Published - Jun 4 2001 |
Keywords
- Azides
- Cycloaddition
- Kinetics
- Molecular recognition
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry