Recognition of an HLA public determinant (Bw4) by human allogeneic cytotoxic T lymphocytes

Carol Clayberger, Mark Rosen, Peter Parham, Alan M. Krensky*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

The human class I HLA molecules are composed of both polymorphic, or private, and conserved, or public, regions. The private regions are recognized by alloreactive T cells and also serve as restriction elements for both peptide presentation to autologous cells. Although the ability of public determinants to elicit antibody responses is well documented, little is known of their role in T cell function. In this study we examine the ability of one of these public HLA determinants, designated Bw4, to serve as a target Ag for CTL. We show that for some individuals the HLA-Bw4 epitope can function as a restriction element for CTL. This finding has important implications for organ transplantation.

Original languageEnglish (US)
Pages (from-to)4172-4176
Number of pages5
JournalJournal of Immunology
Volume144
Issue number11
StatePublished - 1990

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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