Recombinant human factor VIIa in the management of amyloid-associated factor X deficiency

Lisa Boggio; David Green

doi:10.1046/j.1365-2141.2001.02667.x

Recombinant human factor VIIa in the management of amyloid-associated factor X deficiency

Lisa Boggio, David Green^*

^*Corresponding author for this work

Medicine

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

Factor X deficiency is an important complication of amyloidosis. It is associated with severe bleeding that is difficult to control with plasma or prothrombin complex concentrates. Splenectomy ameliorates the factor X deficiency, but achieving satisfactory haemostasis for this operation is problematic. We report that a new clotting concentrate, recombinant factor VIIa, readily controls bleeding and makes splenectomy feasible.

Original language	English (US)
Pages (from-to)	1074-1075
Number of pages	2
Journal	British Journal of Haematology
Volume	112
Issue number	4
DOIs	https://doi.org/10.1046/j.1365-2141.2001.02667.x
State	Published - 2001

Keywords

Amyloid
Factor X deficiency
Haemostasis
Recombinant factor VIIa
Splenectomy

ASJC Scopus subject areas

Hematology

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10.1046/j.1365-2141.2001.02667.x

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title = "Recombinant human factor VIIa in the management of amyloid-associated factor X deficiency",

abstract = "Factor X deficiency is an important complication of amyloidosis. It is associated with severe bleeding that is difficult to control with plasma or prothrombin complex concentrates. Splenectomy ameliorates the factor X deficiency, but achieving satisfactory haemostasis for this operation is problematic. We report that a new clotting concentrate, recombinant factor VIIa, readily controls bleeding and makes splenectomy feasible.",

keywords = "Amyloid, Factor X deficiency, Haemostasis, Recombinant factor VIIa, Splenectomy",

author = "Lisa Boggio and David Green",

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AU - Boggio, Lisa

AU - Green, David

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N2 - Factor X deficiency is an important complication of amyloidosis. It is associated with severe bleeding that is difficult to control with plasma or prothrombin complex concentrates. Splenectomy ameliorates the factor X deficiency, but achieving satisfactory haemostasis for this operation is problematic. We report that a new clotting concentrate, recombinant factor VIIa, readily controls bleeding and makes splenectomy feasible.

AB - Factor X deficiency is an important complication of amyloidosis. It is associated with severe bleeding that is difficult to control with plasma or prothrombin complex concentrates. Splenectomy ameliorates the factor X deficiency, but achieving satisfactory haemostasis for this operation is problematic. We report that a new clotting concentrate, recombinant factor VIIa, readily controls bleeding and makes splenectomy feasible.

KW - Amyloid

KW - Factor X deficiency

KW - Haemostasis

KW - Recombinant factor VIIa

KW - Splenectomy

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ER -

Recombinant human factor VIIa in the management of amyloid-associated factor X deficiency

Abstract

Keywords

ASJC Scopus subject areas

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