Recombinant interferon-α therapy in patients with follicular lymphoma

Howard Ozer*, Peter H. Wiernik, Francis Giles, Craig Tendler

*Corresponding author for this work

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

BACKGROUND. Advanced stage, follicular, non-Hodgkin's lymphoma (NHL) has no cure and no single standard of care. Remissions induced by standard chemotherapy regimens generally are not durable and, with the exception of selected patients with limited early stage disease, most patients with follicular NHL eventually die of their disease. Recombinant interferon-α (rIFN-α) has demonstrated activity against follicular NHL in clinical trials. METHODS. A comprehensive survey of current therapeutic options for follicular NHL patients was conducted with emphasis on the role of rIFN-α used in conjunction with chemotherapy regimens. RESULTS. Phase III studies have demonstrated that rIFN-α delays disease progression and may improve overall survival when administered either with chemotherapy or as maintenance therapy after induction treatment for follicular lymphoma. Adverse effects from combination or maintenance regimens are not significantly different from those from chemotherapy alone. CONCLUSIONS. Recombinant IFN-α is safe and effective when given in conjunction with standard chemotherapeutic regimens in selected patients with follicular NHL, and may especially benefit patients with minimal residual disease after induction chemotherapy.

Original languageEnglish (US)
Pages (from-to)1821-1830
Number of pages10
JournalCancer
Volume82
Issue number10
DOIs
StatePublished - May 15 1998

Keywords

  • Combination chemotherapy
  • Hematology
  • Interferon-α
  • Non-Hodgkin's lymphoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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