@article{229be9591dd0404f9c9825dbdb574b54,
title = "Recombinant Listeria monocytogenes expressing an immunodominant peptide fails to protect after intravaginal challenge with herpes simplex virus-2",
abstract = "Recombinant Listeria monocytogenes expressing a type-common herpes simplex virus (HSV) gB-peptide was shown previously to protect against footpad inoculation with HSV-1. We tested this construct for protection against vaginal challenge with HSV-2. Primed mice demonstrated strong recall responses, had modest reductions in HSV-2 DNA in vaginal mucosa, but were not protected from disease.",
author = "Muller, {William J.} and Orgun, {Nural N.} and Lichun Dong and Koelle, {David M.} and Huang, {Meei Li} and Way, {Sing Sing}",
note = "Funding Information: This work was supported in part by the following grants to SSW: NIH-K08HD51584, a Wyeth Infectious Disease Society of America award, Puget Sound Partners for Global Health, and a March of Dimes Basil O{\textquoteright}Conner starter research award. WJM was supported by NIH grant T32 AI007411 and by a Child Health Research Career Development Award through the Department of Pediatrics, Feinberg School of Medicine, and Children{\textquoteright}s Memorial Research Center at Northwestern University. DMK is supported in part by NIH AI50132. We thank Dr. Gregg Milligan (University of Texas Medical Branch, Galveston, TX) for HSV-2 strain 186, which was grown and titered by Chris McClurkan.",
year = "2008",
month = jun,
doi = "10.1007/s00705-008-0089-7",
language = "English (US)",
volume = "153",
pages = "1165--1169",
journal = "Archives of Virology",
issn = "0304-8608",
publisher = "Springer",
number = "6",
}