Recombinant Listeria monocytogenes expressing an immunodominant peptide fails to protect after intravaginal challenge with herpes simplex virus-2

William J Muller, Nural N. Orgun, Lichun Dong, David M. Koelle, Meei Li Huang, Sing Sing Way

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Recombinant Listeria monocytogenes expressing a type-common herpes simplex virus (HSV) gB-peptide was shown previously to protect against footpad inoculation with HSV-1. We tested this construct for protection against vaginal challenge with HSV-2. Primed mice demonstrated strong recall responses, had modest reductions in HSV-2 DNA in vaginal mucosa, but were not protected from disease.

Original languageEnglish (US)
Pages (from-to)1165-1169
Number of pages5
JournalArchives of Virology
Volume153
Issue number6
DOIs
StatePublished - Jun 1 2008

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Human Herpesvirus 2
Listeria monocytogenes
Peptides
Human Herpesvirus 1
Simplexvirus
Mucous Membrane
DNA

ASJC Scopus subject areas

  • Virology

Cite this

Muller, William J ; Orgun, Nural N. ; Dong, Lichun ; Koelle, David M. ; Huang, Meei Li ; Way, Sing Sing. / Recombinant Listeria monocytogenes expressing an immunodominant peptide fails to protect after intravaginal challenge with herpes simplex virus-2. In: Archives of Virology. 2008 ; Vol. 153, No. 6. pp. 1165-1169.
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Recombinant Listeria monocytogenes expressing an immunodominant peptide fails to protect after intravaginal challenge with herpes simplex virus-2. / Muller, William J; Orgun, Nural N.; Dong, Lichun; Koelle, David M.; Huang, Meei Li; Way, Sing Sing.

In: Archives of Virology, Vol. 153, No. 6, 01.06.2008, p. 1165-1169.

Research output: Contribution to journalArticle

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