Recombinant Listeria monocytogenes expressing an immunodominant peptide fails to protect after intravaginal challenge with herpes simplex virus-2

William J Muller, Nural N. Orgun, Lichun Dong, David M. Koelle, Meei Li Huang, Sing Sing Way

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Recombinant Listeria monocytogenes expressing a type-common herpes simplex virus (HSV) gB-peptide was shown previously to protect against footpad inoculation with HSV-1. We tested this construct for protection against vaginal challenge with HSV-2. Primed mice demonstrated strong recall responses, had modest reductions in HSV-2 DNA in vaginal mucosa, but were not protected from disease.

Original languageEnglish (US)
Pages (from-to)1165-1169
Number of pages5
JournalArchives of Virology
Volume153
Issue number6
DOIs
StatePublished - Jun 1 2008

ASJC Scopus subject areas

  • Virology

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