Recombinant Listeria monocytogenes expressing an immunodominant peptide fails to protect after intravaginal challenge with herpes simplex virus-2

William J. Muller; Nural N. Orgun; Lichun Dong; David M. Koelle; Meei Li Huang; Sing Sing Way

doi:10.1007/s00705-008-0089-7

Recombinant Listeria monocytogenes expressing an immunodominant peptide fails to protect after intravaginal challenge with herpes simplex virus-2

William J. Muller, Nural N. Orgun, Lichun Dong, David M. Koelle, Meei Li Huang, Sing Sing Way

Pediatrics

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Recombinant Listeria monocytogenes expressing a type-common herpes simplex virus (HSV) gB-peptide was shown previously to protect against footpad inoculation with HSV-1. We tested this construct for protection against vaginal challenge with HSV-2. Primed mice demonstrated strong recall responses, had modest reductions in HSV-2 DNA in vaginal mucosa, but were not protected from disease.

Original language	English (US)
Pages (from-to)	1165-1169
Number of pages	5
Journal	Archives of Virology
Volume	153
Issue number	6
DOIs	https://doi.org/10.1007/s00705-008-0089-7
State	Published - Jun 2008

Funding

This work was supported in part by the following grants to SSW: NIH-K08HD51584, a Wyeth Infectious Disease Society of America award, Puget Sound Partners for Global Health, and a March of Dimes Basil O’Conner starter research award. WJM was supported by NIH grant T32 AI007411 and by a Child Health Research Career Development Award through the Department of Pediatrics, Feinberg School of Medicine, and Children’s Memorial Research Center at Northwestern University. DMK is supported in part by NIH AI50132. We thank Dr. Gregg Milligan (University of Texas Medical Branch, Galveston, TX) for HSV-2 strain 186, which was grown and titered by Chris McClurkan.

ASJC Scopus subject areas

Virology

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10.1007/s00705-008-0089-7

Cite this

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title = "Recombinant Listeria monocytogenes expressing an immunodominant peptide fails to protect after intravaginal challenge with herpes simplex virus-2",

abstract = "Recombinant Listeria monocytogenes expressing a type-common herpes simplex virus (HSV) gB-peptide was shown previously to protect against footpad inoculation with HSV-1. We tested this construct for protection against vaginal challenge with HSV-2. Primed mice demonstrated strong recall responses, had modest reductions in HSV-2 DNA in vaginal mucosa, but were not protected from disease.",

author = "Muller, \{William J.\} and Orgun, \{Nural N.\} and Lichun Dong and Koelle, \{David M.\} and Huang, \{Meei Li\} and Way, \{Sing Sing\}",

note = "Funding Information: This work was supported in part by the following grants to SSW: NIH-K08HD51584, a Wyeth Infectious Disease Society of America award, Puget Sound Partners for Global Health, and a March of Dimes Basil O{\textquoteright}Conner starter research award. WJM was supported by NIH grant T32 AI007411 and by a Child Health Research Career Development Award through the Department of Pediatrics, Feinberg School of Medicine, and Children{\textquoteright}s Memorial Research Center at Northwestern University. DMK is supported in part by NIH AI50132. We thank Dr. Gregg Milligan (University of Texas Medical Branch, Galveston, TX) for HSV-2 strain 186, which was grown and titered by Chris McClurkan.",

year = "2008",

month = jun,

doi = "10.1007/s00705-008-0089-7",

language = "English (US)",

volume = "153",

pages = "1165--1169",

journal = "Archives of Virology",

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AU - Muller, William J.

AU - Orgun, Nural N.

AU - Dong, Lichun

AU - Koelle, David M.

AU - Huang, Meei Li

AU - Way, Sing Sing

N1 - Funding Information: This work was supported in part by the following grants to SSW: NIH-K08HD51584, a Wyeth Infectious Disease Society of America award, Puget Sound Partners for Global Health, and a March of Dimes Basil O’Conner starter research award. WJM was supported by NIH grant T32 AI007411 and by a Child Health Research Career Development Award through the Department of Pediatrics, Feinberg School of Medicine, and Children’s Memorial Research Center at Northwestern University. DMK is supported in part by NIH AI50132. We thank Dr. Gregg Milligan (University of Texas Medical Branch, Galveston, TX) for HSV-2 strain 186, which was grown and titered by Chris McClurkan.

PY - 2008/6

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N2 - Recombinant Listeria monocytogenes expressing a type-common herpes simplex virus (HSV) gB-peptide was shown previously to protect against footpad inoculation with HSV-1. We tested this construct for protection against vaginal challenge with HSV-2. Primed mice demonstrated strong recall responses, had modest reductions in HSV-2 DNA in vaginal mucosa, but were not protected from disease.

AB - Recombinant Listeria monocytogenes expressing a type-common herpes simplex virus (HSV) gB-peptide was shown previously to protect against footpad inoculation with HSV-1. We tested this construct for protection against vaginal challenge with HSV-2. Primed mice demonstrated strong recall responses, had modest reductions in HSV-2 DNA in vaginal mucosa, but were not protected from disease.

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Recombinant Listeria monocytogenes expressing an immunodominant peptide fails to protect after intravaginal challenge with herpes simplex virus-2

Abstract

Funding

ASJC Scopus subject areas

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